| Title: | Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine |
| Authors: | Endo, Tsutomu Browse this author |
| Imagama, Shiro Browse this author |
| Kato, Satoshi Browse this author |
| Kaito, Takashi Browse this author |
| Sakai, Hiroaki Browse this author |
| Ikegawa, Shiro Browse this author |
| Kawaguchi, Yoshiharu Browse this author |
| Kanayama, Masahiro Browse this author |
| Hisada, Yuichiro Browse this author |
| Koike, Yoshinao Browse this author |
| Ando, Kei Browse this author |
| Kobayashi, Kazuyoshi Browse this author |
| Oda, Itaru Browse this author |
| Okada, Kazufumi Browse this author |
| Takagi, Ryo Browse this author |
| Iwasaki, Norimasa Browse this author |
| Takahata, Masahiko Browse this author →KAKEN DB |
| Keywords: | vitamin A |
| vitamin B6 |
| dietary habits |
| severe obesity |
| early-onset OPLL |
| heterotopic ossification |
| Issue Date: | Oct-2022 |
| Publisher: | SAGE Publications |
| Journal Title: | Global Spine Journal |
| Volume: | 12 |
| Issue: | 8 |
| Start Page: | 1770 |
| End Page: | 1780 |
| Publisher DOI: | 10.1177/2192568221989300 |
| Abstract: | Study Design: A sex- and age-matched case-control study and a cross-sectional study. Objective: In our previous study, patients with early-onset (<50 years of age) ossification of the posterior longitudinal ligament (OPLL) had distinct features such as morbid obesity, a high prevalence of lifestyle-related diseases, and diffuse ossified lesions mainly affecting the thoracic spine. Our goals were to determine whether early-onset OPLL patients have unbalanced dietary habits and to identify nutritional factors associated with OPLL exacerbation. Methods: In Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age >= 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan. Results: The BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level. Conclusions: Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87323 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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