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Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine

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Title: Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine
Authors: Endo, Tsutomu Browse this author
Imagama, Shiro Browse this author
Kato, Satoshi Browse this author
Kaito, Takashi Browse this author
Sakai, Hiroaki Browse this author
Ikegawa, Shiro Browse this author
Kawaguchi, Yoshiharu Browse this author
Kanayama, Masahiro Browse this author
Hisada, Yuichiro Browse this author
Koike, Yoshinao Browse this author
Ando, Kei Browse this author
Kobayashi, Kazuyoshi Browse this author
Oda, Itaru Browse this author
Okada, Kazufumi Browse this author
Takagi, Ryo Browse this author
Iwasaki, Norimasa Browse this author
Takahata, Masahiko Browse this author →KAKEN DB
Keywords: vitamin A
vitamin B6
dietary habits
severe obesity
early-onset OPLL
heterotopic ossification
Issue Date: Oct-2022
Publisher: SAGE Publications
Journal Title: Global Spine Journal
Volume: 12
Issue: 8
Start Page: 1770
End Page: 1780
Publisher DOI: 10.1177/2192568221989300
Abstract: Study Design: A sex- and age-matched case-control study and a cross-sectional study. Objective: In our previous study, patients with early-onset (<50 years of age) ossification of the posterior longitudinal ligament (OPLL) had distinct features such as morbid obesity, a high prevalence of lifestyle-related diseases, and diffuse ossified lesions mainly affecting the thoracic spine. Our goals were to determine whether early-onset OPLL patients have unbalanced dietary habits and to identify nutritional factors associated with OPLL exacerbation. Methods: In Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age >= 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan. Results: The BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level. Conclusions: Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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