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Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size

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Title: Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size
Authors: Miyashita, Chihiro Browse this author →KAKEN DB
Sasaki, Seiko Browse this author
Ikeno, Tamiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Ito, Sachiko Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Todaka, Takashi Browse this author
Hachiya, Noriyuki Browse this author
Yasutake, Akira Browse this author
Murata, Katsuyuki Browse this author
Nakajima, Tamie Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Polychlorinated biphenyls
Birth size
Small for gestational age
In utero exposure
Polyunsaturated fatty acids
Issue Date: 15-Nov-2015
Publisher: Elsevier
Journal Title: Science of The Total Environment
Volume: 533
Start Page: 256
End Page: 265
Publisher DOI: 10.1016/j.scitotenv.2015.06.108
Abstract: The adverse effects of in utero exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg), and the beneficial effects of nutrients from maternal fish intake might have opposing influences on fetal growth. In this study, we assessed the effects of in utero exposure to PCBs and MeHg on birth size in the Japanese population, which is known to have a high frequency of fish consumption. The concentrations of PCBs and polyunsaturated fatty acids in maternal blood, and the total mercury in hair (as a biomarker of MeHg exposure) were measured during pregnancy and at delivery. Maternal intakes of fish (subtypes: fatty and lean) and shellfishes were calculated from a food frequency questionnaire administered at delivery. Newborn anthropometric measurement data were obtained from birth records. The associations between chemical exposures and birth size were analyzed by using multiple regression analysis with adjustment for confounding factors among 367 mother–newborn pairs. The birth weight was 3073 ± 37 g (mean ± SD). The incidence of babies small for gestational age (SGA) by weight was 4.9%. The median concentrations of total PCBs and hair mercury were 108 ng/g lipid and 1.41 μg/g, respectively. There was no overall association between mercury concentrations and birth weight, birth length, chest circumference, and head circumference. We observed that the risk of SGA by weight decreased with increasing mercury concentration in regression analyses with adjustment for polyunsaturated fatty acids. Our results suggest that the beneficial effect of essential nutrition may mask the adverse effects of MeHg on birth size. The concentrations of PCBs had no association with birth size.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮下 ちひろ

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