| Title: | Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size |
| Authors: | Miyashita, Chihiro Browse this author →KAKEN DB |
| Sasaki, Seiko Browse this author |
| Ikeno, Tamiko Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Ito, Sachiko Browse this author →KAKEN DB |
| Kajiwara, Jumboku Browse this author |
| Todaka, Takashi Browse this author |
| Hachiya, Noriyuki Browse this author |
| Yasutake, Akira Browse this author |
| Murata, Katsuyuki Browse this author |
| Nakajima, Tamie Browse this author |
| Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Polychlorinated biphenyls |
| Methylmercury |
| Birth size |
| Small for gestational age |
| In utero exposure |
| Polyunsaturated fatty acids |
| Issue Date: | 15-Nov-2015 |
| Publisher: | Elsevier |
| Journal Title: | Science of The Total Environment |
| Volume: | 533 |
| Start Page: | 256 |
| End Page: | 265 |
| Publisher DOI: | 10.1016/j.scitotenv.2015.06.108 |
| Abstract: | The adverse effects of in utero exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg), and the beneficial effects of nutrients from maternal fish intake might have opposing influences on fetal growth. In this study, we assessed the effects of in utero exposure to PCBs and MeHg on birth size in the Japanese population, which is known to have a high frequency of fish consumption. The concentrations of PCBs and polyunsaturated fatty acids in maternal blood, and the total mercury in hair (as a biomarker of MeHg exposure) were measured during pregnancy and at delivery. Maternal intakes of fish (subtypes: fatty and lean) and shellfishes were calculated from a food frequency questionnaire administered at delivery. Newborn anthropometric measurement data were obtained from birth records. The associations between chemical exposures and birth size were analyzed by using multiple regression analysis with adjustment for confounding factors among 367 mother–newborn pairs. The birth weight was 3073 ± 37 g (mean ± SD). The incidence of babies small for gestational age (SGA) by weight was 4.9%. The median concentrations of total PCBs and hair mercury were 108 ng/g lipid and 1.41 μg/g, respectively. There was no overall association between mercury concentrations and birth weight, birth length, chest circumference, and head circumference. We observed that the risk of SGA by weight decreased with increasing mercury concentration in regression analyses with adjustment for polyunsaturated fatty acids. Our results suggest that the beneficial effect of essential nutrition may mask the adverse effects of MeHg on birth size. The concentrations of PCBs had no association with birth size. |
| Rights: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87336 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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