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Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children

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Title: Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children
Authors: Mitsui, Takahiko Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Goudarzi, Houman Browse this author
Miyashita, Chihiro Browse this author →KAKEN DB
Ito, Sachiko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author
Kitta, Takeya Browse this author
Moriya, Kimihiko Browse this author
Cho, Kazutoshi Browse this author →KAKEN DB
Morioka, Keita Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Shinohara, Nobuo Browse this author →KAKEN DB
Takeda, Masayuki Browse this author
Nonomura, Katsuya Browse this author →KAKEN DB
Keywords: 2D/4D
Sex differentiation
Issue Date: Sep-2016
Publisher: Elsevier
Journal Title: Steroids
Volume: 113
Start Page: 46
End Page: 51
Publisher DOI: 10.1016/j.steroids.2016.06.009
Abstract: Objectives We investigated the relationship between the levels of adrenal steroid hormones in cord blood and the second to fourth digit ratio (2D/4D), which is regarded as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Materials and methods Of the 514 mother-child pairs who participated in the prospective cohort study of birth in Sapporo between 2002 and 2005, the following adrenal steroid hormone levels in 294 stored cord blood samples (135 males and 159 females) were measured; cortisol, cortisone, androstenedione and dehydroepiandrosterone (DHEA). A total of 190 out of 350 children who were currently school-aged and contactable for this survey sent back photocopies of their palms for 2D/4D measurements. Results 2D/4D in all right hands, left hands, and mean values was significantly lower in males than in females (p < 0.01). DHEA levels were significantly higher in females. A multivariate regression model showed that 2D/4D negatively correlated with DHEA in males only (p < 0.01). No correlations were observed in the other adrenal steroid hormones tested in males or in any adrenal steroid hormones in females. Conclusion DHEA is mainly secreted in large amounts by the adrenal gland and is transformed into active sex-steroid hormones in peripheral tissues. The present study demonstrated that sex differences in digits were influenced by adrenal androgens during the prenatal period, possibly through intracrinological processes for androgen receptors located in fetal cartilaginous tissues.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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