| Title: | Relationship between adrenal steroid hormones in cord blood and birth weight : The Sapporo Cohort, Hokkaido Study on Environment and Children's Health |
| Authors: | Mitsui, Takahiko Browse this author |
| Araki, Atsuko Browse this author →KAKEN DB |
| Goudarzi, Houman Browse this author |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Ito, Sachiko Browse this author →KAKEN DB |
| Sasaki, Seiko Browse this author |
| Kitta, Takeya Browse this author |
| Moriya, Kimihiko Browse this author |
| Cho, Kazutoshi Browse this author →KAKEN DB |
| Morioka, Keita Browse this author |
| Kishi, Reiko Browse this author →KAKEN DB |
| Shinohara, Nobuo Browse this author →KAKEN DB |
| Takeda, Masayuki Browse this author |
| Nonomura, Katsuya Browse this author →KAKEN DB |
| Issue Date: | Jul-2018 |
| Publisher: | John Wiley & Sons |
| Journal Title: | American Journal of Human Biology |
| Volume: | 30 |
| Issue: | 4 |
| Start Page: | e23127 |
| Publisher DOI: | 10.1002/ajhb.23127 |
| Abstract: | Objectives: We investigated the relationship between steroid hormone levels in cord blood and birth weight.
Methods: Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records.
Results: Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females.
Conclusions: Prenatal adrenal steroids as well as converting enzymes such as 11ß-hydrosteroid dehydrogenase type 2 and 3ß-hydrosteroid dehydrogenase may have an impact on prenatal physical development. |
| Rights: | This is the peer reviewed version of the following article: Mitsui, T, Araki, A, Goudarzi, H, et al. Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health. Am J Hum Biol. 2018; 30:e23127, which has been published in final form at https://doi.org/10.1002/ajhb.23127. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87338 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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