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Title: 環境化学物質による次世代の性ホルモンへの影響
Other Titles: Environmental Chemical Exposure and Its Effects on Infants’ Reproductive Hormones
Authors: 荒木, 敦子 Browse this author →KAKEN DB
伊藤, 佐智子 Browse this author →KAKEN DB
宮下, ちひろ Browse this author →KAKEN DB
湊屋, 街子 Browse this author →KAKEN DB
岸, 玲子 Browse this author →KAKEN DB
Keywords: endocrine disruptors
environmental chemicals
reproductive hormones
in utero
declining birthrate
Issue Date: Sep-2018
Publisher: 日本衛生学会
Journal Title: 日本衛生学雑誌
Journal Title(alt): Japanese Journal of Hygiene
Volume: 73
Issue: 3
Start Page: 313
End Page: 321
Publisher DOI: 10.1265/jjh.73.313
Abstract: In recent years, the birthrate has been continuously declining in Japan. The main causes of the decline are social factors. On the other hand, there is increasing evidence that many environmental chemicals show endocrine disrupting properties. Thus, we hypothesized that exposure to these chemicals would also be a causal for the fertility crisis. In this review, we examined current evidence that focused on environmental chemical exposure in utero and its association with reproductive hormones in children. We have included the findings from a prospective birth cohorts, the Hokkaido Study on Environment and Children’s Health Sapporo cohort. According to the literature, environmental chemical levels in utero, such as polychlorinated biphenyl, dioxins, perfluorinated chemical substances, phthalates, and bisphenol A were somewhat asso­ciated with the levels of reproductive hormones, such as testosterone, estradiol, progesterone, inhibin B, and insulin­like factor­3 in cord blood, in early childhood and adolescence. The literature also suggests the associa­tion between exposure to these chemicals and brain­sexual differentiation or the anogenital distance, which suggests the disruption of androgen shower during the developmental stage in the fetal period. There are still knowledge gaps on whether these hormones at an early stage affect the pubertal development and reproduc­tive functions in later life. In addition, alternative chemicals are produced after banning one type. The health effects of alternative chemicals should be evaluated. Effects of exposure to a mixture of the chemicals should also be examined in future studies. In conclusion, the prevention of environmental chemical hazards in relation to human reproductive function is important. It would be one of the countermeasures to the falling birthrate caused by fertility issues.
Description: 総説
シリーズ: 学術研究からの少子化対策-日本衛生学会からの提言に向けて
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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