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Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome

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Title: Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome
Authors: Saito, Rika Browse this author
Kawamoto, Yasuyuki Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author
Iwai, Takahito Browse this author
Kikuchi, Yasuka Browse this author
Yokota, Isao Browse this author
Takagi, Ryo Browse this author
Yamamura, Takahiro Browse this author
Ito, Ken Browse this author
Harada, Kazuaki Browse this author
Yuki, Satoshi Browse this author
Komatsu, Yoshito Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Ultrasonography
Liver stiffness measurement
Shear-wave elastography
Sinusoidal obstruction syndrome
Issue Date: 30-Aug-2022
Publisher: Springer
Journal Title: International journal of clinical oncology
Volume: 27
Issue: 11
Start Page: 1780
End Page: 1790
Publisher DOI: 10.1007/s10147-022-02235-4
Abstract: Background Sinusoidal obstruction syndrome (SOS) refers to liver injury caused by hematopoietic stem cell transplantation (HSCT) and anticancer drugs including oxaliplatin. Increased splenic volume (SV) on computed tomography (CT) indicates oxaliplatin-induced SOS. Similarly, ultrasonography and liver stiffness measurement (LSM) by shear-wave elastography (SWE) can help diagnose SOS after HSCT; however, their usefulness for diagnosing oxaliplatin-induced SOS remains unclear. We investigated the usefulness of the Hokkaido ultrasonography-based scoring system with 10 ultrasonographic parameters (HokUS-10) and SWE in diagnosing oxaliplatin-induced SOS early. Methods In this prospective observational study, ultrasonography and SWE were performed before and at 2, 4, and 6 months after oxaliplatin-based chemotherapy. HokUS-10 was used for assessment. CT volumetry of the SV was performed in clinical practice, and an SV increase >= 30% was considered the diagnostic indicator of oxaliplatin-induced SOS. We assessed whether HokUS-10 and SWE can lead to an early detection of oxaliplatin-induced SOS before an increased SV on CT. Results Of the 30 enrolled patients with gastrointestinal cancers, 12 (40.0%) with an SV increase >= 30% on CT were diagnosed with SOS. The HokUS-10 score was not correlated with an SV increase >= 30% (r = 0.18). The change in rate of three HokUS-10 parameters were correlated with an SV increase >= 30% (r = 0.32-0.41). The change in rate of LSM by SWE was correlated with an SV increase >= 30% (r = 0.40). Conclusions The usefulness of HokUS-10 score was not demonstrated; however, some HokUS-10 parameters and SWE could be useful for the early diagnosis of oxaliplatin-induced SOS.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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