| Title: | Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome |
| Authors: | Saito, Rika Browse this author |
| Kawamoto, Yasuyuki Browse this author →KAKEN DB |
| Nishida, Mutsumi Browse this author |
| Iwai, Takahito Browse this author |
| Kikuchi, Yasuka Browse this author |
| Yokota, Isao Browse this author |
| Takagi, Ryo Browse this author |
| Yamamura, Takahiro Browse this author |
| Ito, Ken Browse this author |
| Harada, Kazuaki Browse this author |
| Yuki, Satoshi Browse this author |
| Komatsu, Yoshito Browse this author →KAKEN DB |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Ultrasonography |
| Liver stiffness measurement |
| Shear-wave elastography |
| Oxaliplatin |
| Sinusoidal obstruction syndrome |
| Issue Date: | 30-Aug-2022 |
| Publisher: | Springer |
| Journal Title: | International journal of clinical oncology |
| Volume: | 27 |
| Issue: | 11 |
| Start Page: | 1780 |
| End Page: | 1790 |
| Publisher DOI: | 10.1007/s10147-022-02235-4 |
| Abstract: | Background Sinusoidal obstruction syndrome (SOS) refers to liver injury caused by hematopoietic stem cell transplantation (HSCT) and anticancer drugs including oxaliplatin. Increased splenic volume (SV) on computed tomography (CT) indicates oxaliplatin-induced SOS. Similarly, ultrasonography and liver stiffness measurement (LSM) by shear-wave elastography (SWE) can help diagnose SOS after HSCT; however, their usefulness for diagnosing oxaliplatin-induced SOS remains unclear. We investigated the usefulness of the Hokkaido ultrasonography-based scoring system with 10 ultrasonographic parameters (HokUS-10) and SWE in diagnosing oxaliplatin-induced SOS early. Methods In this prospective observational study, ultrasonography and SWE were performed before and at 2, 4, and 6 months after oxaliplatin-based chemotherapy. HokUS-10 was used for assessment. CT volumetry of the SV was performed in clinical practice, and an SV increase >= 30% was considered the diagnostic indicator of oxaliplatin-induced SOS. We assessed whether HokUS-10 and SWE can lead to an early detection of oxaliplatin-induced SOS before an increased SV on CT. Results Of the 30 enrolled patients with gastrointestinal cancers, 12 (40.0%) with an SV increase >= 30% on CT were diagnosed with SOS. The HokUS-10 score was not correlated with an SV increase >= 30% (r = 0.18). The change in rate of three HokUS-10 parameters were correlated with an SV increase >= 30% (r = 0.32-0.41). The change in rate of LSM by SWE was correlated with an SV increase >= 30% (r = 0.40). Conclusions The usefulness of HokUS-10 score was not demonstrated; however, some HokUS-10 parameters and SWE could be useful for the early diagnosis of oxaliplatin-induced SOS. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87344 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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