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ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons

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Title: ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons
Authors: Hasebe, Rie Browse this author
Murakami, Kaoru Browse this author
Harada, Masaya Browse this author
Halaka, Nada Browse this author
Nakagawa, Hiroshi Browse this author
Kawano, Fuminori Browse this author
Ohira, Yoshinobu Browse this author
Kawamoto, Tadafumi Browse this author
Yull, Fiona E. E. Browse this author
Blackwell, Timothy S. S. Browse this author
Nio-Kobayashi, Junko Browse this author
Iwanaga, Toshihiko Browse this author
Watanabe, Masahiko Browse this author
Watanabe, Nobuhiro Browse this author
Hotta, Harumi Browse this author
Yamashita, Toshihide Browse this author
Kamimura, Daisuke Browse this author
Tanaka, Yuki Browse this author
Murakami, Masaaki Browse this author →KAKEN DB
Keywords: Innate immunity and inflammation
Issue Date: 6-Jun-2022
Publisher: Rockefeller University Press
Journal Title: Journal of experimental medicine
Volume: 219
Issue: 6
Start Page: e20212019
Publisher DOI: 10.1084/jem.20212019
Abstract: Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron–interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. These results suggest blockade of this neural pathway, which is named the remote inflammation gateway reflex, may have therapeutic value for inflammatory diseases, particularly those, such as rheumatoid arthritis, in which inflammation spreads to remote positions.
Rights: ©2022 Hasebe et al. Originally published in Journal of experimental medicine.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 村上 正晃

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