| Title: | ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons |
| Authors: | Hasebe, Rie Browse this author |
| Murakami, Kaoru Browse this author |
| Harada, Masaya Browse this author |
| Halaka, Nada Browse this author |
| Nakagawa, Hiroshi Browse this author |
| Kawano, Fuminori Browse this author |
| Ohira, Yoshinobu Browse this author |
| Kawamoto, Tadafumi Browse this author |
| Yull, Fiona E. E. Browse this author |
| Blackwell, Timothy S. S. Browse this author |
| Nio-Kobayashi, Junko Browse this author |
| Iwanaga, Toshihiko Browse this author |
| Watanabe, Masahiko Browse this author |
| Watanabe, Nobuhiro Browse this author |
| Hotta, Harumi Browse this author |
| Yamashita, Toshihide Browse this author |
| Kamimura, Daisuke Browse this author |
| Tanaka, Yuki Browse this author |
| Murakami, Masaaki Browse this author →KAKEN DB |
| Keywords: | Innate immunity and inflammation |
| Neuroscience |
| Issue Date: | 6-Jun-2022 |
| Publisher: | Rockefeller University Press |
| Journal Title: | Journal of experimental medicine |
| Volume: | 219 |
| Issue: | 6 |
| Start Page: | e20212019 |
| Publisher DOI: | 10.1084/jem.20212019 |
| Abstract: | Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron–interneuron crosstalk, with ATP at the core. Surgical ablation or pharmacological inhibition of this neural pathway prevented inflammation development on the other side. Mechanistic analysis showed that ATP serves as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induces inflammation on the other side. These results suggest blockade of this neural pathway, which is named the remote inflammation gateway reflex, may have therapeutic value for inflammatory diseases, particularly those, such as rheumatoid arthritis, in which inflammation spreads to remote positions. |
| Rights: | ©2022 Hasebe et al. Originally published in Journal of experimental medicine. https://doi.org/10.1084/jem.20212019 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87375 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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