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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Progressive multifocal leukoencephalopathy with mild clinical conditions and detection of archetype-like JC virus in cerebrospinal fluid
| Title: | Progressive multifocal leukoencephalopathy with mild clinical conditions and detection of archetype-like JC virus in cerebrospinal fluid |
| Authors: | Iwami, Kosuke Browse this author | | Nakamichi, Kazuo Browse this author | | Matsushima, Masaaki Browse this author →ORCID | | Nagai, Azusa Browse this author | | Shirai, Shinichi Browse this author | | Nakakubo, Sho Browse this author | | Takahashi-Iwata, Ikuko Browse this author | | Yamada, Masafumi Browse this author | | Yabe, Ichiro Browse this author →KAKEN DB |
| Keywords: | Progressive multifocal leukoencephalopathy | | JC virus | | Non-coding control region | | VP1 gene | | Combined immunodeficiency |
| Issue Date: | 1-Dec-2021 |
| Publisher: | Springer |
| Journal Title: | Journal of Neurovirology |
| Volume: | 27 |
| Issue: | 6 |
| Start Page: | 917 |
| End Page: | 922 |
| Publisher DOI: | 10.1007/s13365-021-01017-4 |
| Abstract: | Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system with a poor prognosis and is primarily caused by JC virus (JCV) with a mutation called prototype. We encountered a case of PML with moderate progression and analyzed the mutational patterns of JCV in the cerebrospinal fluid (CSF). A 19-year-old Japanese woman with mild neurological symptoms was diagnosed with combined immunodeficiency following pneumocystis pneumonia. Brain magnetic resonance imaging scan showed multiple brain lesions, and real-time polymerase chain reaction testing detected JCV in the CSF, leading to the diagnosis of PML. The disease course of PML was stable after administration of mefloquine and mirtazapine with immunoglobulin replacement therapy. In the JCV genome cloned from the patient CSF, DNA sequences of the gene encoding the capsid protein (VP1) and the non-coding control region exhibited small mutations. However, they were quite similar to those of the archetype JCV, which persists asymptomatically in healthy individuals. These findings provide insight into the mutational characteristics of JCV in PML with mild symptoms and progression. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87380 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松島 理明
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