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Crohn's Disease Activity Evaluation by Transabdominal Ultrasonography Correlation with Double-Balloon Endoscopy

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Title: Crohn's Disease Activity Evaluation by Transabdominal Ultrasonography Correlation with Double-Balloon Endoscopy
Authors: Yamanashi, Kana Browse this author
Katsurada, Takehiko Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author
Onishi, Reizo Browse this author
Omotehara, Satomi Browse this author
Otagiri, Shinsuke Browse this author
Sakurai, Kensuke Browse this author
Nagashima, Kazunori Browse this author
Kinoshita, Kenji Browse this author
Takagi, Ryo Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Crohn’s disease
disease activity
double‐balloon endoscopy
small intestine
transabdominal ultrasonography
Issue Date: Dec-2021
Publisher: John Wiley & Sons
Journal Title: Journal of ultrasound in medicine
Volume: 40
Issue: 12
Start Page: 2595
End Page: 2605
Publisher DOI: 10.1002/jum.15645
Abstract: Objectives Transabdominal ultrasonography (US) has been reported as a useful tool for evaluating Crohn's disease (CD) activity. Endoscopic findings and Crohn's disease activity index (CDAI) are currently considered the gold standard for assessing CD activity. We assessed the correlation between US and double-balloon endoscopy (DBE), and CDAI for evaluating CD activity. Methods We analyzed patients with CD undergoing US and DBE within 10 days between the procedures. The intestine was divided into four segments and analyzed by the US scoring system (US-CD) and the simple endoscopic score for Crohn's disease (SES-CD). CDAI was compared with US-CD and SES-CD. Spearman's rank correlation coefficient was used for statistical analysis. Results Twenty-five patients with CD (11 women, 14 men; mean age 35.4 +/- 14.9 years, range 16-65 years) were enrolled. Twenty-four patients received antitumor necrosis factor inhibitor therapy. CDAI was 128.1 (range 36-227). A significant moderate correlation was found between the US-CD and SES-CD in all segments (rho = .64, P < .01). The US-CD showed a strong correlation with CDAI (rho = .78, P < .01), whereas the SES-CD showed a moderate correlation (rho = .55, P < .05). Conclusions US-CD and SES-CD showed a moderate correlation for assessing CD activity. US-CD showed a stronger correlation with CDAI than SES-CD, suggesting that US could more accurately evaluate the disease activity.
Rights: This is the peer reviewed version of the following article: Yamanashi, K., Katsurada, T., Nishida, M., Onishi, R., Omotehara, S., Otagiri, S., Sakurai, K., Nagashima, K., Kinoshita, K., Takagi, R. and Sakamoto, N. (2021), Crohn's Disease Activity Evaluation by Transabdominal Ultrasonography: Correlation with Double-Balloon Endoscopy. J Ultrasound Med, 40: 2595-2605, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 桂田 武彦

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