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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma
| Title: | A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma |
| Authors: | Tsutsumi, Yutaka Browse this author | | Ito, Shinich Browse this author | | Kobayashi, Mirei Browse this author | | Teshima, Takanori Browse this author →KAKEN DB |
| Issue Date: | 3-Oct-2022 |
| Publisher: | Hindawi Publishing Corporation |
| Journal Title: | Case reports in hematology |
| Volume: | 2022 |
| Start Page: | 3076968 |
| Publisher DOI: | 10.1155/2022/3076968 |
| Abstract: | A 68-year-old woman presented with follicular lymphoma complicated by IgG kappa-positive multiple myeloma. In this case, both follicular lymphoma and plasma cells were positive for BCL2 by immunostaining. T-cell association in the FL and MM was also analyzed in this case. Some CD3-positive T-cells were found around the plasma cells. These cells were mainly CD8-positive T-cells and not CD4-positive T-cells. These results suggest that CD4-positive T-cells were not associated with the proliferation of the plasma cells in this case. Although the FL that developed was initially positive for BCL2 protein, this does not indicate that plasma cells were derived from FL cells because of the eventual complication that occurred in this case. Furthermore, in this case, rituximab and bendamustine were effective for FL. They were not effective for MM, however, demonstrating that additional treatment options are necessary for the simultaneous treatment of BCL2-positive MM with FL. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87393 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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