A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/87491

Title:	A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole
Authors:	Matsuo, Kazuya Browse this author
	Thayyil, Sampreeth Browse this author
	Kawaguchi, Mitsuyasu Browse this author
	Nakagawa, Hidehiko Browse this author
	Tamaoki, Nobuyuki Browse this author →KAKEN DB
Issue Date:	4-Dec-2021
Publisher:	Royal Society of Chemistry
Journal Title:	Chemical communications
Volume:	57
Issue:	93
Start Page:	12500
End Page:	12503
Publisher DOI:	10.1039/d1cc04905d
Abstract:	Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine-threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. The reversible trans-cis isomerization by visible light stimuli enabled us to manipulate ROCK activities in vitro and in cells.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/87491
Appears in Collections:	電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉置信之

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