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Autophagy during left ventricular redilation after ventrictuoulasty : Insights from a rat model of ischemic cardiomyopathy

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Title: Autophagy during left ventricular redilation after ventrictuoulasty : Insights from a rat model of ischemic cardiomyopathy
Authors: Sugimoto, Satoshi Browse this author
Shingu, Yasushige Browse this author →KAKEN DB
Doenst, Torsten Browse this author
Yamakawa, Tomoji Browse this author
Asai, Hidetsugu Browse this author
Wakasa, Satoru Browse this author →KAKEN DB
Matsui, Yoshiro Browse this author →KAKEN DB
Keywords: ischemic cardiomyopathy
left ventriculoplasty
left ventricular redilation
myocardial hypertrophy
Issue Date: 1-Jan-2022
Publisher: Elsevier
Journal Title: Journal of Thoracic and Cardiovascular Surgery
Volume: 163
Issue: 1
Start Page: e33
End Page: e40
Publisher DOI: 10.1016/j.jtcvs.2020.01.080
Abstract: Objectives: Myocardial autophagy has been recognized as an important factor in heart failure. It is not known whether changes in ventricular geometry by left ventriculoplasty influence autophagy in ischemic cardiomyopathy. We hypothesized that myocardial autophagy plays an important role in left ventricular (LV) redilation after ventriculoplasty. Methods: Four weeks after ligation of the left anterior descending artery, ventriculoplasty or sham operation was performed. The animals were euthanized at 2 days (early) or 28 days (late) after the second operation. Ventricular autophagy was evaluated by protein expression of microtubule-associated protein light chain 3 II, an autophagosome marker. Cardiomyocyte area was assessed by histologic examination. LV function was evaluated by echocardiography. To examine the implications of autophagy, an autophagy inhibitor (3-methyladenine) was injected intraperitoneally for 3 weeks before sacrifice. Results: The LV was reduced in size early and redilated late after ventriculoplasty. LV systolic function was improved early and later worsened after ventriculoplasty. Light chain 3 II expression decreased early after ventriculoplasty and increased in the late period. Myocyte area increased from the early to late stage after ventriculoplasty. Autophagic inhibition exaggerated the increased myocyte hypertrophy and LV redilation. Conclusions: In a rat model of myocardial infarction, autophagy decreased early after ventriculoplasty and increased again during LV redilation. These results provide new insights into the mechanism underlying the late failure of ventriculoplasty.
Rights: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新宮 康栄

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