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SARS-CoV-2 Omicron detection by antigen tests using saliva

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Title: SARS-CoV-2 Omicron detection by antigen tests using saliva
Authors: Murakami, Kaoru Browse this author
Iwasaki, Sumio Browse this author
Oguri, Satoshi Browse this author
Tanaka, Kumiko Browse this author
Suzuki, Rigel Browse this author
Hayasaka, Kasumi Browse this author
Fujisawa, Shinichi Browse this author
Watanabe, Chiaki Browse this author
Konno, Satoshi Browse this author
Yokota, Isao Browse this author
Fukuhara, Takasuke Browse this author
Murakami, Masaaki Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Keywords: SARS-CoV-2
Issue Date: Nov-2022
Publisher: Elsevier
Journal Title: Journal of Clinical Virology Plus
Volume: 2
Issue: 4
Start Page: 100109
Publisher DOI: 10.1016/j.jcvp.2022.100109
Abstract: The Omicron emerged in November 2021 and became the predominant SARS-CoV-2 variant globally. It spreads more rapidly than ancestral lineages and its rapid detection is critical for the prevention of disease outbreaks. Antigen tests such as immunochromatographic assay (ICA) and chemiluminescent enzyme immunoassay (CLEIA) yield results more quickly than standard polymerase chain reaction (PCR). However, their utility for the detec-tion of the Omicron variant remains unclear. We herein evaluated the performance of ICA and CLEIA in saliva from 51 patients with Omicron and 60 PCR negative individuals. The sensitivity and specificity of CLEIA were 98.0% (95%CI: 89.6-100.0%) and 100.0% (95%CI: 94.0-100.0%), respectively, with fine correlation with cy-cle threshold (Ct) values. The sensitivity and specificity of ICA were 58.8% (95%CI: 44.2-72.4%) and 100.0% (95%CI: 94.0-100.0%), respectively. The sensitivity of ICA was 100.0% (95%CI: 80.5-100.0%) when PCR Ct was less than 25. The Omicron can be efficiently detected in saliva by CLEIA. ICA also detects high viral load Omicron using saliva.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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