Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
SARS-CoV-2 Omicron detection by antigen tests using saliva
Title: | SARS-CoV-2 Omicron detection by antigen tests using saliva |
Authors: | Murakami, Kaoru Browse this author | Iwasaki, Sumio Browse this author | Oguri, Satoshi Browse this author | Tanaka, Kumiko Browse this author | Suzuki, Rigel Browse this author | Hayasaka, Kasumi Browse this author | Fujisawa, Shinichi Browse this author | Watanabe, Chiaki Browse this author | Konno, Satoshi Browse this author | Yokota, Isao Browse this author | Fukuhara, Takasuke Browse this author | Murakami, Masaaki Browse this author | Teshima, Takanori Browse this author →KAKEN DB |
Keywords: | SARS-CoV-2 | COVID-19 | Saliva | Lumipulse | ICA | CLEIA |
Issue Date: | Nov-2022 |
Publisher: | Elsevier |
Journal Title: | Journal of Clinical Virology Plus |
Volume: | 2 |
Issue: | 4 |
Start Page: | 100109 |
Publisher DOI: | 10.1016/j.jcvp.2022.100109 |
Abstract: | The Omicron emerged in November 2021 and became the predominant SARS-CoV-2 variant globally. It spreads more rapidly than ancestral lineages and its rapid detection is critical for the prevention of disease outbreaks. Antigen tests such as immunochromatographic assay (ICA) and chemiluminescent enzyme immunoassay (CLEIA) yield results more quickly than standard polymerase chain reaction (PCR). However, their utility for the detec-tion of the Omicron variant remains unclear. We herein evaluated the performance of ICA and CLEIA in saliva from 51 patients with Omicron and 60 PCR negative individuals. The sensitivity and specificity of CLEIA were 98.0% (95%CI: 89.6-100.0%) and 100.0% (95%CI: 94.0-100.0%), respectively, with fine correlation with cy-cle threshold (Ct) values. The sensitivity and specificity of ICA were 58.8% (95%CI: 44.2-72.4%) and 100.0% (95%CI: 94.0-100.0%), respectively. The sensitivity of ICA was 100.0% (95%CI: 80.5-100.0%) when PCR Ct was less than 25. The Omicron can be efficiently detected in saliva by CLEIA. ICA also detects high viral load Omicron using saliva. |
Type: | article |
URI: | http://hdl.handle.net/2115/87648 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|