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Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality ; The Japan Collaborative Cohort Study

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Title: Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality ; The Japan Collaborative Cohort Study
Authors: Matsunaga, Masaaki Browse this author
Yatsuya, Hiroshi Browse this author
Iso, Hiroyasu Browse this author
Li, Yuanying Browse this author
Yamagishi, Kazumasa Browse this author
Tanabe, Naohito Browse this author
Wada, Yasuhiko Browse this author
Ota, Atsuhiko Browse this author
Tamakoshi, Koji Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Body mass index
Cardiovascular disease
Issue Date: 1-Oct-2022
Publisher: Japan Atherosclerosis Society (日本動脈硬化学会) JAS
Journal Title: Journal of atherosclerosis and thrombosis
Volume: 29
Issue: 10
Start Page: 1547
End Page: 1562
Publisher DOI: 10.5551/jat.63143
Abstract: Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.Methods: We studied 102,535 participants aged 40-79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (<18.5, 18.5-20.9, 21.0- 22.9 [reference], 23.0-24.9, 25.0-27.4, and >= 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25-27.4 and >= 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI >= 25 kg/m2 for obesity-related cancer was -0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.Conclusion: A BMI >= 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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