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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality ; The Japan Collaborative Cohort Study
| Title: | Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality ; The Japan Collaborative Cohort Study |
| Authors: | Matsunaga, Masaaki Browse this author | | Yatsuya, Hiroshi Browse this author | | Iso, Hiroyasu Browse this author | | Li, Yuanying Browse this author | | Yamagishi, Kazumasa Browse this author | | Tanabe, Naohito Browse this author | | Wada, Yasuhiko Browse this author | | Ota, Atsuhiko Browse this author | | Tamakoshi, Koji Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB |
| Keywords: | Body mass index | | Overweight | | Obesity | | Cancer | | Cardiovascular disease |
| Issue Date: | 1-Oct-2022 |
| Publisher: | Japan Atherosclerosis Society (日本動脈硬化学会) JAS |
| Journal Title: | Journal of atherosclerosis and thrombosis |
| Volume: | 29 |
| Issue: | 10 |
| Start Page: | 1547 |
| End Page: | 1562 |
| Publisher DOI: | 10.5551/jat.63143 |
| Abstract: | Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.Methods: We studied 102,535 participants aged 40-79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (<18.5, 18.5-20.9, 21.0- 22.9 [reference], 23.0-24.9, 25.0-27.4, and >= 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25-27.4 and >= 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI >= 25 kg/m2 for obesity-related cancer was -0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.Conclusion: A BMI >= 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87649 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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