HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Combination of strategies to initiate clozapine for refractory schizophrenia in a patient with low neutrophil levels

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Combination of strategies to initiate clozapine for refractory schizophrenia in a patient with low neutrophil levels
Authors: Takanobu, Keisuke Browse this author
Hashimoto, Naoki Browse this author
Ishikawa, Shuhei Browse this author
Kusumi, Ichiro Browse this author
Keywords: Psychiatry (drugs and medicines)
Haematology (incl blood transfusion)
Issue Date: 13-Oct-2022
Publisher: BMJ Publishing Group
Journal Title: BMJ Case Reports
Volume: 15
Issue: 10
Start Page: e247734
Publisher DOI: 10.1136/bcr-2021-247734
Abstract: Clozapine is the only drug with confirmed efficacy for refractory schizophrenia; however, its use is restricted due to the risk of potentially life-threatening side effects, such as agranulocytosis. Although this restriction ensures safety against haematological risks, some patients with refractory schizophrenia who have low neutrophil levels may miss the opportunity to receive clozapine treatment. We herein report the case of a patient with refractory schizophrenia and low neutrophil levels who was successfully initiated on clozapine treatment after the use of several methods for increasing neutrophil levels. These strategies consisted of discontinuation of antipsychotics, treatment with lithium carbonate and adenine, and light exercise before blood testing. Combining these procedures may be an effective option in the treatment of patients with refractory schizophrenia whose neutrophil levels are not sufficient to initiate clozapine.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University