|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
Clinical significance of serum and vitreous soluble interleukin-2 receptor in patients with intraocular lymphoma
| Title: | Clinical significance of serum and vitreous soluble interleukin-2 receptor in patients with intraocular lymphoma |
| Authors: | Suzuki, Kayo Browse this author | | Namba, Kenichi Browse this author →KAKEN DB | | Kase, Satoru Browse this author | | Ogino, Yo Browse this author | | Hase, Keitaro Browse this author | | Iwata, Daiju Browse this author | | Mizuuchi, Kazuomi Browse this author | | Hiraoka, Miki Browse this author | | Kitaichi, Nobuyoshi Browse this author | | Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | Soluble interleukin-2 receptor | | Matrix metalloproteinases | | Intraocular lymphoma | | Vitreoretinal lymphoma | | Central nervous system lymphoma |
| Issue Date: | 10-Nov-2022 |
| Publisher: | BioMed Central |
| Journal Title: | BMC ophthalmology |
| Volume: | 22 |
| Issue: | 1 |
| Start Page: | 428 |
| Publisher DOI: | 10.1186/s12886-022-02677-4 |
| Abstract: | Background Intraocular lymphoma (IOL) is a masquerade syndrome that mimics uveitis, making diagnosis difficult. The serum soluble interleukin-2 receptor (sIL-2R), which is cleaved by matrix metalloproteinase (MMP) -2 and MMP-9, has been recognized as a tumor-related biomarker of malignant lymphomas. The aim of this study was to review the reliability of serum and vitreous sIL-2R for distinguishing IOL from uveitis. Methods Patients who underwent diagnostic vitrectomy for marked vitreous haze at Hokkaido University Hospital between April 2014 and June 2019 were enrolled. The patients were divided into an IOL group and a uveitis group, according to the pathology of their vitreous samples. The IOL group was further divided at the time of vitrectomy into patients who already had extraocular involvement (IOL with extraocular involvement group) and patients with no evidence of having extraocular involvement (IOL without extraocular involvement group). Serum sIL-2R, and intravitreal sIL-2R, MMP-2, and MMP-9 levels were assessed. Results Twenty-five eyes of 25 patients, and 15 eyes of 15 patients were included in the IOL group and uveitis group, respectively. The serum sIL-2R levels were significantly lower in the IOL group than in the uveitis group (P < 0.05), and 20.0% and 66.7% in the IOL and the uveitis group showed high sIL-2R value above the normal range. Vitreous sIL-2R tended to be higher in the IOL group than in the uveitis group (P = 0.80). Serum sIL-2R was significantly lower in the IOL without extraocular involvement group than in the IOL with extraocular involvement group (P < 0.05); 5.9% in the IOL without extraocular involvement group and 50.0% in the IOL with extraocular involvement group showed high sIL-2R value above the normal range. Vitreous sIL-2R, MMP-2, and MMP-9 tended to be higher in the IOL with extraocular involvement group than in the IOL without extraocular involvement group (P = 0.30, < 0.05, 0.16). Conclusions Serum sIL-2R is often within the normal range in IOL patients. Even if it is within the normal range, the possibility of IOL should be considered. Serum sIL-2R is not a reliable biomarker for IOL, whereas vitreous sIL-2R may be useful for the diagnosis of IOL. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87797 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
