HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis : A preliminary observational study

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis : A preliminary observational study
Authors: Abe, Nobuya Browse this author
Kono, Michihiro Browse this author
Kono, Michihito Browse this author
Katsuyama, Takayuki Browse this author
Ohmura, Kazumasa Browse this author
Sato, Taiki Browse this author
Karino, Kohei Browse this author
Fujieda, Yuichiro Browse this author
Kato, Masaru Browse this author
Hasebe, Rie Browse this author
Murakami, Masaaki Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: large vessel vasculitis
Takayasu arteritis
giant cell arteritis
Janus-kinase inhibitor
Issue Date: 23-Nov-2023
Publisher: Frontiers Media
Journal Title: Frontiers in immunology
Volume: 13
Start Page: 1066916
Publisher DOI: 10.3389/fimmu.2022.1066916
Abstract: Large-vessel vasculitis (LVV) is subclassified into two phenotypes; Takayasu arteritis and giant cell arteritis. Although the pathogenesis of LVV is not fully established, IL-6-IL-17 axis and IL-12-IFN-gamma axis play critical roles in the disease development. We aimed to clarify the association between the disease state and cytokine/chemokine levels, to assess disease course as prognosis and to predict regulators in patients with LVV using the blood profiles of multiple cytokines/chemokines. This retrospective analysis comprised 35 LVV patients whose blood were collected, and multiplex cytokine/chemokine analysis with 28 analytes was performed. The differences of cytokines/chemokines corresponding disease status, upstream regulator analysis, pathway analysis and cluster analysis were conducted using the cytokines/chemokines profile. Relapse-free survival rate was calculated with Kaplan-Meier analysis in the classified clusters. In the robust analysis, IL-4, CCL2/MCP-1, TNFSF13/APRIL, TNFSF13B/BAFF, CHI3L1 and VEGF-A levels were significantly changed after treatment. Untreated LVV patients demonstrated activation of NF kappa B-related molecules and these patients are potentially treated with JAK/STAT inhibitors, anti-TNF-alpha inhibitors and IL-6 inhibitors. Cluster analysis in active LVV patients revealed two clusters including one with high blood levels of IL-1 beta, IL-6, IL-17, IL-23 and CCL20/MIP-3. A subgroup of the LVV patients showed activated IL-17 signature with high relapse frequency, and JAK/TyK2 inhibitors and IFN-gamma inhibitors were detected as potentially upstream inhibitors. Blood cytokine/chemokine profiles would be useful for prediction of relapse and potentially contributes to establish therapeutic strategy as precision medicine in LVV patients.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University