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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma
| Title: | Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma |
| Authors: | Wang, Jingting Browse this author | | Wang, Nan Browse this author | | Zheng, Zeyu Browse this author | | Che, Yanlu Browse this author | | Suzuki, Masanobu Browse this author | | Kano, Satoshi Browse this author | | Lu, Jianguang Browse this author | | Wang, Peng Browse this author | | Sun, Yanan Browse this author | | Homma, Akihiro Browse this author →KAKEN DB |
| Keywords: | lncRNA HOTAIR | | Exosomes | | Macrophage | | LSCC | | EMT |
| Issue Date: | 24-Nov-2022 |
| Publisher: | BioMed Central |
| Journal Title: | BMC cancer |
| Volume: | 22 |
| Issue: | 1 |
| Start Page: | 1208 |
| Publisher DOI: | 10.1186/s12885-022-10210-5 |
| Abstract: | Exosomes are a new way of the communication between the tumor cell and macrophage in the micro-environment. The macrophage can be induced to different phenotypes according to the different tumors. In the present study, long-chain noncoding RNA HOTAIR (lncRNA HOTAIR) was highly expressed in LSCC and exosomes. The pathway of exosomal lncRNA HOTAIR inducing macrophage to M2 polarization in the LSCC was investigated. The carcinoma tissues and adjacent tissues were collected from 104 LSCC cases, and the positive relationship between CD163-/CD206-M2 macrophage infiltration and clinical phase, lymph node spreading and pathological phase in LSCC was observed. To examine the role of exosomal lncRNA HOTAIR, macrophages were co-cultured with LSCC-exosomes of high lncRNA HOTAIR expression or transferred with HOTAIR mimics. It was suggested that exosomal lncRNA HOTAIR can induce macrophages to M2 polarization by PI3K/p-AKT/AKT signaling pathway. Furthermore, exo-treated M2 macrophages facilitate the migration, proliferation, and EMT of LSCC. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87823 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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