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Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia

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Title: Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia
Authors: Nakata, Hokuto Browse this author
Nakayama, Shouta M. M. Browse this author
Yabe, John Browse this author
Muzandu, Kaampwe Browse this author
Toyomaki, Haruya Browse this author
Yohannes, Yared Beyene Browse this author
Kataba, Andrew Browse this author
Zyambo, Golden Browse this author
Ikenaka, Yoshinori Browse this author
Choongo, Kennedy Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Liver function
Kidney function
ALAD activity
Mining site
Issue Date: Jan-2021
Publisher: Elsevier
Journal Title: Chemosphere
Volume: 262
Start Page: 127788
Publisher DOI: 10.1016/j.chemosphere.2020.127788
Abstract: Lead (Pb) interferes with various bodily functions. Although high blood Pb (Pb-B) levels in residents from Kabwe, Zambia have been reported, the accumulation pattern of other metals remains unknown. The study was designed to determine the Pb-B, blood cadmium (Cd-B), and zinc (Zn-B) values of 504 representative samples from Kabwe, as well as the potential associated adverse health effects. The Pb-B level ranged from 0.79 to 154.75 mu g/dL and generally increased in areas near the mine. A significant elevation of Cd-B was observed in two areas (0.37 +/- 0.26 and 0.32 +/- 0.30 mu g/L) where the two highest mean Pb-B levels were recorded. By contrast, the Zn-B values did not differ greatly with respect to area. Some blood biochemical parameters relating to hepatic and renal functions were out of the normal range in approximately 20-50% of studied adult participants. The delta-aminolevulinic acid dehydratase (delta -ALAD) activity was significantly inhibited in the two areas contaminated by Pb and Cd. A significant negative relationship was observed between metal levels and clinical parameters, e.g., between Pb-B and delta -ALAD for all the age categories and between Cd-B and the estimated glomerular filtration rate for all the age categories except 0-4 years. The elevated Cd-B in areas near the mine relative to the other areas suggested the potential adverse health effects of Cd and/or the interaction of Pb and Cd. A significant association of metal levels with clinical parameters also indicated the effects of metal exposure on hematopoietic, hepatic, and renal systems. (C) 2020 Elsevier Ltd. All rights reserved.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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