| Title: | Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia |
| Authors: | Nakata, Hokuto Browse this author |
| Nakayama, Shouta M. M. Browse this author |
| Yabe, John Browse this author |
| Muzandu, Kaampwe Browse this author |
| Toyomaki, Haruya Browse this author |
| Yohannes, Yared Beyene Browse this author |
| Kataba, Andrew Browse this author |
| Zyambo, Golden Browse this author |
| Ikenaka, Yoshinori Browse this author |
| Choongo, Kennedy Browse this author |
| Ishizuka, Mayumi Browse this author →KAKEN DB |
| Keywords: | Liver function |
| Kidney function |
| ALAD activity |
| Lead |
| Cadmium |
| Mining site |
| Issue Date: | Jan-2021 |
| Publisher: | Elsevier |
| Journal Title: | Chemosphere |
| Volume: | 262 |
| Start Page: | 127788 |
| Publisher DOI: | 10.1016/j.chemosphere.2020.127788 |
| Abstract: | Lead (Pb) interferes with various bodily functions. Although high blood Pb (Pb-B) levels in residents from Kabwe, Zambia have been reported, the accumulation pattern of other metals remains unknown. The study was designed to determine the Pb-B, blood cadmium (Cd-B), and zinc (Zn-B) values of 504 representative samples from Kabwe, as well as the potential associated adverse health effects. The Pb-B level ranged from 0.79 to 154.75 mu g/dL and generally increased in areas near the mine. A significant elevation of Cd-B was observed in two areas (0.37 +/- 0.26 and 0.32 +/- 0.30 mu g/L) where the two highest mean Pb-B levels were recorded. By contrast, the Zn-B values did not differ greatly with respect to area. Some blood biochemical parameters relating to hepatic and renal functions were out of the normal range in approximately 20-50% of studied adult participants. The delta-aminolevulinic acid dehydratase (delta -ALAD) activity was significantly inhibited in the two areas contaminated by Pb and Cd. A significant negative relationship was observed between metal levels and clinical parameters, e.g., between Pb-B and delta -ALAD for all the age categories and between Cd-B and the estimated glomerular filtration rate for all the age categories except 0-4 years. The elevated Cd-B in areas near the mine relative to the other areas suggested the potential adverse health effects of Cd and/or the interaction of Pb and Cd. A significant association of metal levels with clinical parameters also indicated the effects of metal exposure on hematopoietic, hepatic, and renal systems. (C) 2020 Elsevier Ltd. All rights reserved. |
| Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/87839 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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