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Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study

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Title: Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study
Authors: Nakamura, Koshi Browse this author
Hui, Shu-Ping Browse this author
Ukawa, Shigekazu Browse this author
Okada, Emiko Browse this author
Nakagawa, Takafumi Browse this author
Imae, Akihiro Browse this author
Okabe, Hiroaki Browse this author
Chen, Zhen Browse this author
Miura, Yusuke Browse this author
Chiba, Hitoshi Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: 25-hydroxyvitamin D3
insulin resistance
Issue Date: Jan-2023
Publisher: 日本疫学会(Japan Epidemiological Association)JEA
Journal Title: Journal of epidemiology
Volume: 33
Issue: 1
Start Page: 31
End Page: 37
Publisher DOI: 10.2188/jea.JE20210007
Abstract: Background: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency.Methods: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level >= 126 mg/dL and/or a HbA1c level >= 6.5%, among 480 participants aged 35-79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model.Results: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: <= 18.10, 18.11-22.90, and 22.91-28.17 ng/mL) were 4.02 (95% confidence interval [CI], 1.25-12.92), 2.50 (95% CI, 0.77-8.10), and 1.91 (95% CI, 0.60-6.09), respectively, with the fourth quartile group (> 28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized beta = -0.08; 95% CI, -0.14 to -0.02).Conclusion: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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