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Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis

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Title: Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis
Authors: Sakurai, Kensuke Browse this author
Katsurada, Takehiko Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author →KAKEN DB
Omotehara, Satomi Browse this author
Fukushima, Shinya Browse this author
Otagiri, Shinsuke Browse this author
Nagashima, Kazunori Browse this author
Onishi, Reizo Browse this author
Takagi, Ryo Browse this author
Komatsu, Yoshito Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Transabdorninal ultrasonography
Immune-mediated colitis
Immune checkpoint inhibitor
Immune-related adverse events
Issue Date: Jan-2023
Publisher: Korean Association for the Study of Intestinal Diseases
Journal Title: Intestinal Research
Volume: 21
Issue: 1
Start Page: 126
End Page: 136
Publisher DOI: 10.5217/ir.2021.00166
Abstract: Background/Aims: The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced by immune checkpoint inhibitor, and examine the correlation between US findings, colonoscopy (CS) findings, and severity of colitis. Methods: We studied patients examined using CS and US upon suspicion of IMC in Hokkaido University Hospital between April 2018 and February 2021. Endoscopic findings of IMC were assessed using the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). The severity of US findings in IMC was evaluated using US grade, which is the ultrasonographic grading scale in ulcerative colitis. Bowel wall thickness and the intensity of the color Doppler signal were also analyzed. Severity of colitis was evaluated using Common Terminology Criteria for Adverse Events (CFCAE) grade version 5. Results: Fourteen patients with LMC were enrolled. The US findings were bowel wall thickening, loss of stratification, ulceration and increased blood flow signal. The US grade was moderately correlated with the UCEIS (r= 0.687, P = 0.009) and CTCAE grade (r= 0.628, P= 0.035). Bowel wall thickness and UCEIS (r= 0.628, P= 0.020), as well as color Doppler signal grade and CTCAE grade (r= 0.724, P= 0.008), were significantly correlated. Conclusions: US findings in IMC were mainly similar to those of ulcerative colitis, but there were some findings that were characteristic only of LMC. Significant correlation was found between US findings, CS findings, and severity of colitis. Hence, US could be useful for the evaluation of IMC.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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