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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
An Adolescent Patient With Idiopathic Pulmonary Arterial Hypertension Weaned Off Intravenous Epoprostenol Following Treatment With Selexipag : A Case Report
| Title: | An Adolescent Patient With Idiopathic Pulmonary Arterial Hypertension Weaned Off Intravenous Epoprostenol Following Treatment With Selexipag : A Case Report |
| Authors: | Chida-Nagai, Ayako Browse this author | | Tsujioka, Takao Browse this author | | Sasaki, Daisuke Browse this author | | Izumi, Gaku Browse this author | | Yamazawa, Hirokuni Browse this author →KAKEN DB | | Takeda, Atsuhito Browse this author →KAKEN DB |
| Keywords: | pulmonary arterial hypertension | | epoprostenol | | drug transition | | adolescence | | selexipag |
| Issue Date: | 17-Jun-2022 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in Pediatrics |
| Volume: | 10 |
| Start Page: | 909595 |
| Publisher DOI: | 10.3389/fped.2022.909595 |
| Abstract: | Idiopathic pulmonary arterial hypertension (PAH) is a rare, progressive disease affecting the pulmonary arteries. Epoprostenol, a synthetic prostaglandin analog, is the most potent pharmacological treatment modality used in patients with PAH. However, it requires continuous intravenous infusion, which negatively impacts the patient's quality of life and frequently results in complications, such as catheter-related bloodstream infection. We weaned an adolescent female patient off epoprostenol by gradually introducing oral selexipag over a sustained period, following many years of continuous intravenous epoprostenol use alone. Oral selexipag might have an efficacy comparable to epoprostenol in young patients with PAH. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/87999 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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