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Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma
| Title: | Association of longitudinal changes in quality of life with comorbidities and exacerbations in patients with severe asthma |
| Authors: | Matsumoto-Sasaki, Machiko Browse this author | | Suzuki, Masaru Browse this author →KAKEN DB | | Kimura, Hirokazu Browse this author | | Shimizu, Kaoruko Browse this author | | Makita, Hironi Browse this author | | Nishimura, Masaharu Browse this author | | Konno, Satoshi Browse this author →KAKEN DB |
| Keywords: | Comorbidities | | Exacerbation | | Longitudinal assessment | | Quality of life | | Severe asthma |
| Issue Date: | Oct-2022 |
| Publisher: | Japanese Society Allergology |
| Journal Title: | Allergology international |
| Volume: | 71 |
| Issue: | 4 |
| Start Page: | 481 |
| End Page: | 489 |
| Publisher DOI: | 10.1016/j.alit.2022.05.009 |
| Abstract: | Background: Quality of life (QoL) assessment is important in the management of severe asthma, and comorbidities and/or exacerbations may affect longitudinal QoL. However, there are few reports on the longitudinal assessment of QoL in patients with asthma over multiple years and its related factors. This study aimed to clarify the relationship of longitudinal changes in QoL with comorbidities and/or exacerbations during a prolonged observation period in patients with severe asthma. Methods: A total of 105 subjects who participated in the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) with a six-year follow-up were analyzed. QoL was assessed annually, using the Standardized Asthma Quality of Life Questionnaire, and the subjects were divided into three groups: (1) persistently good QoL, (2) persistently poor QoL, and (3) fluctuating QoL. Assessed comorbidities comprised depression, gastroesophageal reflux disease, and excessive daytime sleepiness (EDS), a key symptom of obstructive sleep apnea. Results: Of 105 subjects with severe asthma, 53 (50%) were classified in the persistently good QoL group, 10 (10%) in the persistently poor QoL group, and 42 (40%) in the fluctuating QoL group. The persistently poor QoL group was associated with shorter time to hospitalization due to exacerbation and the presence of multiple comorbidities. In addition, the presence of EDS was an independent contributor to the fluctuating QoL group compared to the persistently good QoL group. Conclusions: The presence of multiple comorbidities and hospitalization due to exacerbation contribute to longitudinal changes in QoL in patients with severe asthma. Copyright (c) 2022, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88010 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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