| Title: | Feasibility of edoxaban for asymptomatic cancer-associated thrombosis in Japanese patients with gastrointestinal cancer : ExCAVE study |
| Authors: | Nakamura, Michio Browse this author |
| Ishiguro, Atsushi Browse this author |
| Dazai, Masayoshi Browse this author |
| Kawamoto, Yasuyuki Browse this author |
| Yuki, Satoshi Browse this author |
| Sogabe, Susumu Browse this author |
| Hosokawa, Ayumu Browse this author |
| Sawada, Kentaro Browse this author |
| Muto, Osamu Browse this author |
| Izawa, Naoki Browse this author |
| Nakashima, Koji Browse this author |
| Horie, Yoshiki Browse this author |
| Yagisawa, Masataka Browse this author |
| Kajiura, Shinya Browse this author |
| Ando, Takayuki Browse this author |
| Mitsuhashi, Yosuke Browse this author |
| Sunakawa, Yu Browse this author |
| Kikuchi, Yasuka Browse this author |
| Komatsu, Yoshito Browse this author →KAKEN DB |
| Keywords: | Thrombosis |
| Edoxaban |
| Gastrointestinal cancer |
| Bleeding |
| Heparin |
| Issue Date: | 16-Dec-2022 |
| Publisher: | BioMed Central |
| Journal Title: | BMC cancer |
| Volume: | 22 |
| Issue: | 1 |
| Start Page: | 1322 |
| Publisher DOI: | 10.1186/s12885-022-10403-y |
| Abstract: | Background: Although initial therapy with a parenteral anticoagulant is required before edoxaban, this strategy is frequently avoided in actual clinical practice because of its complexity. This study assessed the feasibility of edoxaban without initial heparin usage for asymptomatic cancer-associated thrombosis (CAT) in Japanese patients with gastrointestinal cancer (GIC) at high risk of bleeding. Methods: In this multicenter prospective feasibility study conducted at 10 Japanese institutions, patients with active GIC who developed accidental asymptomatic CAT during chemotherapy were recruited. Edoxaban was orally administered once daily without initial parenteral anticoagulant therapy within 3 days after detecting asymptomatic CAT. The primary outcome was the incidence of major bleeding (MB) or clinically relevant non-major bleeding (CRNMB) during the first 3 months of edoxaban administration. Results: Of the 54 patients enrolled from October 2017 to September 2020, one was excluded because of a misdiagnosis of CAT. In the remaining 53 patients, the primary outcome occurred in six patients (11.3%). MB occurred in four patients (7.5%), including gastrointestinal bleeding in three patients and intracranial hemorrhage in one patient. CRNMB occurred in two patients (3.8%), including bleeding from the stoma site and genital bleeding in one patient each. There were no deaths attributable to bleeding, and all patients who experienced MB or CRNMB recovered. Conclusions: The risk of bleeding after edoxaban without heparin pretreatment was acceptable, demonstrating new treatment options for asymptomatic CAT in patients with GIC. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88085 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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