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Hokkaido University Collection of Scholarly and Academic Papers >
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Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy
| Title: | Salvage surgery improves the treatment outcome of patients with residual/recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiation therapy |
| Authors: | Tsushima, Nayuta Browse this author →KAKEN DB | | Kano, Satoshi Browse this author | | Suzuki, Takayoshi Browse this author | | Idogawa, Hiroshi Browse this author | | Yoshida, Daisuke Browse this author | | Yasuda, Koichi Browse this author | | Otsuka, Manami Browse this author | | Aoyama, Hidefumi Browse this author | | Homma, Akihiro Browse this author →KAKEN DB |
| Keywords: | Maxillary sinus cancer | | Salvage surgery | | Intra-arterial | | Chemotherapy | | Radio therapy | | Unresectable |
| Issue Date: | 1-Feb-2022 |
| Publisher: | Springer |
| Journal Title: | European Archives of Oto-Rhino-Laryngology |
| Volume: | 279 |
| Issue: | 2 |
| Start Page: | 899 |
| End Page: | 905 |
| Publisher DOI: | 10.1007/s00405-021-06822-5 |
| Abstract: | Purpose We have performed superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT) for patients with maxillary sinus cancer. The promising treatment outcomes of this non-surgical treatment were reported in past studies. However, few clinical studies have been conducted to evaluate the outcome of salvage surgery following RADPLAT. The purpose of this study was to analyze the treatment outcomes of salvage surgery for patients with recurrent maxillary sinus cancer after RADPLAT. Methods We assessed 45 patients who had recurrence following RADPLAT between 1999 and 2017, and conducted a retrospective analysis. We excluded patients who did not complete RADPLAT. Patients were not considered to have completed RADPLAT if they underwent intra-arterial cisplatin less than three times or received a total radiation dose of less than 60 Gy. The primary endpoint was overall survival. The median follow-up period for surviving patients after recurrence was 5.1 years. Results Twenty-five of the 45 (56%) patients underwent salvage surgery. The 5-year overall survival rate was 68% in patients who underwent salvage surgery, while all patients who did not undergo salvage surgery died during the observation period. Fifteen of 24 (63%) patients with local recurrence underwent salvage surgery. Eight patients did not undergo salvage surgery because of unresectable disease; five of the eight patients had unresectable posterior extension. All nine patients with nodal recurrence underwent neck dissection. Conclusion Treatment outcomes of salvage surgery following RADPLAT were favorable enough for it to be generally recommended. To reduce unresectable recurrence, the posterior section should be eradicated by RADPLAT. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in European Archives of Oto-Rhino-Laryngology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00405-021-06822-5 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88120 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 本間 明宏
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