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Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery

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Title: Thymoma-Related Stiff-Person Syndrome with Successfully Treated by Surgery
Authors: Sasaki, Akihiro Browse this author
Kato, Tatsuya Browse this author
Ujiie, Hideki Browse this author
Wakasa, Satoru Browse this author →KAKEN DB
Otake, Setsuyuki Browse this author
Kikuchi, Keisuke Browse this author
Ohno, Koichi Browse this author
Keywords: stiff-person syndrome
paraneoplastic stiff-person syndrome
anti-acetylcholine receptor antibody
myasthenia gravis
Issue Date: 2022
Publisher: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
Journal Title: Annals of thoracic and cardiovascular surgery
Volume: 28
Issue: 6
Start Page: 448
End Page: 452
Publisher DOI: 10.5761/
Abstract: Introduction: Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder. Paraneoplastic SPS associated with malignant tumors such as thymoma occurs in approx-imately 5% of all SPS cases. We present a rare case of thymoma accompanied by SPS successfully treated using surgery.Presentation of Case: A 26-year-old woman presented with lower limbs convulsions and gait disturbance and complained of leg pain. Cerebrospinal fluid and blood test results showed a high level of anti-glutamic acid decarboxylase (GAD) antibodies. Computed tomography showed anterior mediastinal tumor suggestive of a thymoma. She underwent extended thymectomy, and her symptoms gradually improved after surgery. No evidence of recurrent thymoma and SPS has been observed over 44 months.Conclusion: Surgical treatment would be effective for patients with SPS and thymoma.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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