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Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation

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Title: Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
Authors: Wang, Zhi Jian Browse this author
Jiang, Julong Browse this author
Mu, Qifeng Browse this author
Maeda, Satoshi Browse this author →KAKEN DB
Nakajima, Tasuku Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Keywords: Polymers
Bond cleavage
Issue Date: 23-Feb-2022
Publisher: American Chemical Society
Journal Title: Journal of the American Chemical Society
Volume: 144
Issue: 7
Start Page: 3154
End Page: 3161
Publisher DOI: 10.1021/jacs.1c12539
Abstract: Double-network (DN) hydrogels have recently been demonstrated to generate numerous radicals by the homolytic bond scission of the brittle first network under the influence of an external force. The mechanoradicals thus generated can be utilized to trigger polymerization inside the gels, resulting in significant mechanical and functional improvements to the material. Although the concentration of mechanoradicals in DN gels is much higher than that in single-network hydrogels, a further increase in the mechanoradical concentration in DN gels will widen their application. In the present work, we incorporate an azoalkane crosslinker into the first network of DN gels. Compared with the traditional crosslinker N,N'-methylenebis(acrylamide), the azoalkane crosslinker causes a decrease in the yield stress but significantly increases the mechanoradical concentration of DN gels after stretching. In the azoalkane-crosslinked DN gels, the concentration of mechanoradicals can reach a maximum of similar to 220 mu M, which is 5 times that of the traditional crosslinker. In addition, DN gels with the azoalkane crosslinker show a much higher energy efficiency for mechanoradical generation. Interestingly, DN gels crosslinked by a mixture of azoalkane crosslinker and traditional crosslinker also exhibit excellent radical generation performance. The increase in the mechanoradical concentration accelerates polymerization and can broaden the application range of force-responsive DN gels to biomedical devices and soft robots.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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