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Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

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Title: Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy
Authors: Hieda, Tetsuya Browse this author
Shingu, Yasushige Browse this author →KAKEN DB
Sugimoto, Satoshi Browse this author
Asai, Hidetsugu Browse this author
Yamakawa, Tomoji Browse this author
Wakasa, Satoru Browse this author →KAKEN DB
Keywords: Autophagy
Ischemic cardiomyopathy
Surgical ventricular reconstruction
Issue Date: 1-Mar-2022
Publisher: Springer
Journal Title: Heart and vessels
Volume: 37
Issue: 3
Start Page: 528
End Page: 537
Publisher DOI: 10.1007/s00380-021-01990-0
Abstract: Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 II (LC3-II) and p62; the former usually increases and the latter decreases if autophagy is activated. Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.
Rights: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新宮 康栄

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