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Volume 53, Number 1-2 >

Identification of heat shock protein 70 in canine reticulocytes and mature erythrocytes

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Title: Identification of heat shock protein 70 in canine reticulocytes and mature erythrocytes
Authors: Jeong, Ja-Ryong Browse this author
Yamasaki, Masahiro Browse this author →KAKEN DB
Komatsu, Tomohiko Browse this author
Inaba, Mutsumi Browse this author →KAKEN DB
Yamato, Osamu Browse this author
Maede, Yoshimitsu Browse this author →KAKEN DB
Keywords: canine Hsp 70
erythrocyte maturation
reticulocyte lysate
Issue Date: Aug-2005
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 53
Issue: 1-2
Start Page: 37
End Page: 46
Abstract: In the present study, we demonstrated that heat shock protein 70 (Hsp70) was present in both canine reticulocytes and mature erythrocytes, and that the canine Hsp 70 in reticulocytes was decreased along with the maturation of the cells into erythrocytes. These results suggest that the Hsp 70 in canine reticulocytes might act as a chaperone to remove unnecessary proteins during reticulocyte maturation. We also demonstrated that Hsp 70 was present in exosomes from reticulocytes during their maturation in in vitro culture. Furthermore, the concentration of Hsp 70 in reticulocyte membranes was increased in proportion to an increase of the protein in exosomes until 48 hours after the incubation of reticulocytes in vitro. At 96 hours of the incubation, however, only a trace amount of Hsp 70 was detected in the membrane, while a large amount of the protein was present in the exosomes. These results suggest that Hsp 70 in canine reticulocytes might play an important role for exosome formation in reticulocytes, resulting in the maturation of the cells.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 53, Number 1-2

Submitter: 獣医学部図書室

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