|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Glycogen synthase kinase 3 beta/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO
Title: | Glycogen synthase kinase 3 beta/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO |
Authors: | Abe, Nobuya Browse this author | Kono, Michihito Browse this author →KAKEN DB | Kono, Michihiro Browse this author | Ohnishi, Naoki Browse this author | Sato, Tomoya Browse this author | Tarumi, Masato Browse this author | Yoshimura, Masaru Browse this author | Sato, Taiki Browse this author | Karino, Kohei Browse this author | Shimizu, Yuka Browse this author | Fujieda, Yuichiro Browse this author | Kato, Masaru Browse this author | Hasebe, Rie Browse this author | Oku, Kenji Browse this author | Murakami, Masaaki Browse this author →KAKEN DB | Atsumi, Tatsuya Browse this author →KAKEN DB |
Keywords: | multicentric Castleman disease-TAFRO | lymphoproliferative disorders | chemokine | bone marrow | glycogen synthase 3 |
Issue Date: | Mar-2022 |
Publisher: | John Wiley & Sons |
Journal Title: | British journal of haematology |
Volume: | 196 |
Issue: | 5 |
Start Page: | 1194 |
End Page: | 1204 |
Publisher DOI: | 10.1111/bjh.17993 |
Abstract: | Multicentric Castleman disease-thrombocytopenia, anasarca, reticulin fibrosis of bone marrow, renal dysfunction and organomegaly (MCD-TAFRO)-is an emergent phenotype characterized by lymphoproliferation, fluid collection, hemocytopenia and multiple organopathy. Although studies have demonstrated an aberrant blood cytokine/chemokine profile referred to as "chemokine storm", the pathogenesis remains unclear. We aimed to identify pathogenic key molecules, potential diagnostic targets and therapeutic markers in MCD-TAFRO using serum cytokine/chemokine profiles. We performed the targeted cytokine/chemokine multiplex analysis in six cases of MCD-TAFRO with remission or non-remission status. We observed significant changes in serum concentrations of CCL2, CCL5, and Chitinase-3-like-1 in the MCD-TAFRO patients with active state compared to inactive state. Ingenuity pathway analysis revealed that glycogen synthase kinase 3 (GSK3) and CCR6, which is expressed in megakaryocytes, were detected as upstream positive regulators for activating MCD-TAFRO status. More GSK3 beta(+)CCR6(+) cells like megakaryocytes were detected in the bone marrow of patients with MCD-TAFRO than in those with systemic lupus erythematosus, MCD-not otherwise specified or autoimmune haemophagocytic lymphohistiocytosis. The cellularity of GSK3 beta(+)CCR6(+) cells was correlated with disease activity, including thrombocytopenia and anaemia. In conclusion, GSK3 beta and CCR6 of bone marrow cells were potentially involved in the pathogenesis of MCD-TAFRO and may act as diagnostic targets and therapeutic markers. |
Rights: | Abe, N., Kono, M., Kono, M., Ohnishi, N., Sato, T., Tarumi, M., Yoshimura, M., Sato, T., Karino, K., Shimizu, Y., Fujieda, Y., Kato, M., Hasebe, R., Oku, K., Murakami, M. and Atsumi, T. (2022), Glycogen synthase kinase 3β/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO. Br J Haematol, 196: 1194-1204,which has been published in final form at 10.1111/bjh.17993. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html). |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/88234 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 河野 通仁
|