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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females
| Title: | Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females |
| Authors: | Watanabe, Haruhisa Browse this author | | Iori, Takashi Browse this author | | Lee, Ji-Won Browse this author →KAKEN DB | | Kajii, Takashi S. S. Browse this author | | Takakura, Aya Browse this author | | Takao-Kawabata, Ryoko Browse this author | | Kitagawa, Yoshimasa Browse this author →KAKEN DB | | Maruoka, Yutaka Browse this author →KAKEN DB | | Iimura, Tadahiro Browse this author →KAKEN DB |
| Keywords: | CCL5 | | temporomandibular joint | | degenerative joint disease | | mandible | | joint | | bone metabolism | | osteoarthritis |
| Issue Date: | 1-Feb-2023 |
| Publisher: | MDPI |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 24 |
| Issue: | 3 |
| Start Page: | 2775 |
| Publisher DOI: | 10.3390/ijms24032775 |
| PMID: | 36769097 |
| Abstract: | Degenerative joint disease of the temporomandibular joints (DJD-TMJ) clinically manifests with symptoms such as orofacial pain, joint sounds and limited jaw movements. Our research group previously reported the functional necessity of a chemokine-chemokine receptor axis of CCL5-CCR5 in osteoclasts. Accumulated studies reported that this axis was involved in the pathogenesis of bone and joint destructive diseases, suggesting CCL5 as a potent biomarker. This study investigated whether or not the serum level of CCL5 can be a biomarker of DJD-TMJ and concomitantly analyzed changes in the serum and urine levels of bone markers to see whether or not changes in the rate of bone metabolism were predisposing. We enrolled 17 female subjects with diagnosed DJD-TMJ and sexually and age-matched 17 controls. The serum CCL5 level in DJD-TMJ subjects was significantly higher than that in the control subjects. Multivariate analyses indicated an association between an augmented CCL5 level and the rate of bone metabolism, especially in relatively young DJD-TMJ subjects without other systemic symptoms. A principal component analysis of serum markers and our pharmacological experiment using a postmenopausal model of ovariectomized rats suggested that an augmented serum CCL5 level specifically reflected DJD-TMJ and that covert changes in the rate of bone metabolism predisposed individuals to DJD-TMJ. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88548 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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