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Scallop aquaculture has a potential risk of natto-induced hypersensitivity reactions in a local area of northern Japan
| Title: | Scallop aquaculture has a potential risk of natto-induced hypersensitivity reactions in a local area of northern Japan |
| Authors: | Kurotori, Isaku Browse this author | | Kimura, Takashi Browse this author | | Sasao, Wataru Browse this author | | Abe, Masahiko Browse this author | | Kumagai, Hideki Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB |
| Keywords: | Anaphylaxis | | Cnidaria | | Fisheries | | Food hypersensitivity | | Soy foods |
| Issue Date: | Jan-2023 |
| Publisher: | Japanese Society Allergology |
| Journal Title: | Allergology international |
| Volume: | 72 |
| Issue: | 1 |
| Start Page: | 128 |
| End Page: | 134 |
| Publisher DOI: | 10.1016/j.alit.2022.06.003 |
| Abstract: | Background: Fermented soybean (natto)-induced hypersensitivity reactions (natto allergy) are rare and can result in late-onset anaphylaxis. The allergen in natto is considered to be poly-g-glutamic acid (PGA), and marine sports are a risk factor for natto allergy due to epicutaneous sensitization to PGA from cnidarian stings. However, no research on natto allergy in fishery workers has yet been performed. Methods: We conducted a chart review of inpatients diagnosed with anaphylaxis due to natto at Hokkaido Prefectural Haboro Hospital between April 1, 2009, and August 31, 2020. We also administered selfreport questionnaires about food hypersensitivity reactions to Japanese fishery workers, including members of the Kitarumoi Fishery Cooperative Association and part-time workers in this area, from February 1 to May 31, 2021.Results: We found six inpatients (29 inpatients with food-induced anaphylaxis among approximately 11,000 community-dwelling residents) with late-onset anaphylaxis due to natto; all were involved in scallop aquaculture. The questionnaires revealed that 27 participants had natto allergy. We divided the fishery workers into a scallop aquaculture (Scallop) group (n = 211) and other fishery group (n = 106). The Scallop group was significantly associated with natto allergy after adjustments for confounders (OR: 5.73, 95% CI: 1.46-22.56) by logistic regression analysis. In the Scallop group, older age, experience in repairing nets, and a longer length of work experience were significantly related to participants with natto allergy (n = 23), but not participants without natto allergy (n = 181).Conclusions: Our results indicated an association between scallop aquaculture and natto allergy. (c) 2022 Japanese Society of Allergology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88645 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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