| Title: | Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques |
| Authors: | Ohno, Marumi Browse this author →KAKEN DB |
| Sagata, Masataka Browse this author |
| Sekiya, Toshiki Browse this author →KAKEN DB |
| Nomura, Naoki Browse this author |
| Shingai, Masashi Browse this author →KAKEN DB |
| Endo, Masafumi Browse this author |
| Kimachi, Kazuhiko Browse this author |
| Suzuki, Saori Browse this author |
| Nguyen, Cong Thanh Browse this author →KAKEN DB |
| Nakayama, Misako Browse this author →KAKEN DB |
| Ishigaki, Hirohito Browse this author →KAKEN DB |
| Ogasawara, Kazumasa Browse this author →KAKEN DB |
| Itoh, Yasushi Browse this author →KAKEN DB |
| Kino, Yoichiro Browse this author |
| Kida, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Inactivated whole influenza virus particle |
| vaccine |
| Pyrogenicity |
| Issue Date: | 16-Jan-2023 |
| Publisher: | Elsevier |
| Journal Title: | Vaccine |
| Volume: | 41 |
| Issue: | 3 |
| Start Page: | 787 |
| End Page: | 794 |
| Publisher DOI: | 10.1016/j.vaccine.2022.12.020 |
| Abstract: | Among inactivated influenza vaccines, the whole virus particle vaccine (WPV) elicits superior priming responses to split virus vaccine (SV) in efficiently inducing humoral and cellular immunity. However, there is concern for undesired adverse events such as fever for WPV due to its potent immunogenicity. Therefore, this study investigated the febrile response induced by subcutaneous injection with quadriva-lent inactivated influenza vaccines of good manufacturing grade for pharmaceutical or investigational products in cynomolgus macaques. Body temperature was increased by 1 degrees C-2 degrees C for 6-12 h after WPV administration at the first vaccination but not at the second shot, whereas SV did not affect body temperature at both points. Given the potent priming ability of WPV, WPV-induced fever may be attrib-uted to immune responses that uniquely occur during priming. Since WPV-induced fever was blunted by pretreatment with indomethacin (a cyclooxygenase inhibitor), the febrile response by WPV is considered to depend on the increase in prostaglandins synthesized by cyclooxygenase. In addition, WPV, but not SV, induced the elevation of type I interferons and monocyte chemotactic protein 1 in the plasma; these fac-tors may be responsible for pyrogenicity caused by WPV, as they can increase prostaglandins in the brain. Notably, sufficient antibody responses were acquired by half the amount of WPV without causing fever, suggesting that excessive immune responses to trigger the febrile response is not required for acquired immunity induction. Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naive populations. (c) 2022 The Authors. Published by Elsevier Ltd. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88659 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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