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Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques

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Title: Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques
Authors: Ohno, Marumi Browse this author →KAKEN DB
Sagata, Masataka Browse this author
Sekiya, Toshiki Browse this author →KAKEN DB
Nomura, Naoki Browse this author
Shingai, Masashi Browse this author →KAKEN DB
Endo, Masafumi Browse this author
Kimachi, Kazuhiko Browse this author
Suzuki, Saori Browse this author
Nguyen, Cong Thanh Browse this author →KAKEN DB
Nakayama, Misako Browse this author →KAKEN DB
Ishigaki, Hirohito Browse this author →KAKEN DB
Ogasawara, Kazumasa Browse this author →KAKEN DB
Itoh, Yasushi Browse this author →KAKEN DB
Kino, Yoichiro Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: Inactivated whole influenza virus particle
Issue Date: 16-Jan-2023
Publisher: Elsevier
Journal Title: Vaccine
Volume: 41
Issue: 3
Start Page: 787
End Page: 794
Publisher DOI: 10.1016/j.vaccine.2022.12.020
Abstract: Among inactivated influenza vaccines, the whole virus particle vaccine (WPV) elicits superior priming responses to split virus vaccine (SV) in efficiently inducing humoral and cellular immunity. However, there is concern for undesired adverse events such as fever for WPV due to its potent immunogenicity. Therefore, this study investigated the febrile response induced by subcutaneous injection with quadriva-lent inactivated influenza vaccines of good manufacturing grade for pharmaceutical or investigational products in cynomolgus macaques. Body temperature was increased by 1 degrees C-2 degrees C for 6-12 h after WPV administration at the first vaccination but not at the second shot, whereas SV did not affect body temperature at both points. Given the potent priming ability of WPV, WPV-induced fever may be attrib-uted to immune responses that uniquely occur during priming. Since WPV-induced fever was blunted by pretreatment with indomethacin (a cyclooxygenase inhibitor), the febrile response by WPV is considered to depend on the increase in prostaglandins synthesized by cyclooxygenase. In addition, WPV, but not SV, induced the elevation of type I interferons and monocyte chemotactic protein 1 in the plasma; these fac-tors may be responsible for pyrogenicity caused by WPV, as they can increase prostaglandins in the brain. Notably, sufficient antibody responses were acquired by half the amount of WPV without causing fever, suggesting that excessive immune responses to trigger the febrile response is not required for acquired immunity induction. Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naive populations. (c) 2022 The Authors. Published by Elsevier Ltd.
Type: article
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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