HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2
Authors: Nakazawa, Daigo Browse this author →KAKEN DB
Takeda, Yohei Browse this author
Kanda, Masatoshi Browse this author
Tomaru, Utano Browse this author
Ogawa, Haruko Browse this author
Kudo, Takashi Browse this author
Shiratori-Aso, Satoka Browse this author
Watanabe-Kusunoki, Kanako Browse this author
Ueda, Yusho Browse this author
Miyoshi, Atsuko Browse this author
Hattanda, Fumihiko Browse this author
Nishio, Saori Browse this author
Uozumi, Ryo Browse this author
Ishizu, Akihiro Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: granulocytes
low-density granulocytes
neutrophil extracellular traps
severe COVID-19
Issue Date: Jan-2023
Publisher: John Wiley & Sons
Journal Title: Febs open bio
Volume: 13
Issue: 1
Start Page: 60
End Page: 71
Publisher DOI: 10.1002/2211-5463.13500
Abstract: Severe coronavirus disease 2019 (COVID-19) is characterized by acute respiratory distress syndrome and multiple organ dysfunction, in which the host immune response plays a pivotal role. Excessive neutrophil activation and subsequent superfluity of neutrophil extracellular traps (NETs) can lead to tissue damage, and several studies have shown the involvement of neutrophils in severe COVID-19. However, the detailed responses of each neutrophil subset to SARS-CoV-2 infection has not been fully described. To explore this issue, we incubated normal-density granulocytes (NDGs) and low-density granulocytes (LDGs) with different viral titers of SARS-CoV-2. NDGs form NETs with chromatin fibers in response to SARS-CoV-2, whereas LDGs incubated with SARS-CoV-2 display a distinct morphology with condensed nuclei and moderate transcriptional changes. Based on these transcriptional changes, we suggest that AGO2 possibly plays a role in LDG regulation in response to SARS-CoV-2.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University