|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Center for Environmental and Health Sciences >
Peer-reviewed Journal Articles, etc >
Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus : The Japan Environment and Children's Study
| Title: | Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus : The Japan Environment and Children's Study |
| Authors: | Saito, Yoshihiro Browse this author | | Kobayashi, Sumitaka Browse this author →KAKEN DB | | Ito, Sachiko Browse this author →KAKEN DB | | Miyashita, Chihiro Browse this author →KAKEN DB | | Umazume, Takeshi Browse this author →KAKEN DB | | Cho, Kazutoshi Browse this author →KAKEN DB | | Watari, Hidemichi Browse this author →KAKEN DB | | Ito, Yoshiya Browse this author | | Saijo, Yasuaki Browse this author | | Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Gestational diabetes mellitus | | Neurodevelopment | | Offspring |
| Issue Date: | Dec-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of diabetes investigation |
| Volume: | 13 |
| Issue: | 12 |
| Start Page: | 2054 |
| End Page: | 2062 |
| Publisher DOI: | 10.1111/jdi.13907 |
| Abstract: | Aims/Introduction This study aimed to investigate the neurodevelopment of infants born to women with gestational diabetes mellitus (GDM). Materials and Methods Data from the National Birth Cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 81,705) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The Japanese translation of the Ages and Stages Questionnaires, third Edition, was used to assess neurodevelopment in the following domains: communication skills, gross motor skills, fine motor skills, problem-solving ability, and personal and social skills. The survey was carried out every 6 months from the age of 6 months to 4 years (total of eight times). Generalized estimating equations were used to evaluate the association between maternal GDM and neurodevelopmental delay based on odds ratios (ORs) and 95% confidence intervals (95% CIs). Results Neurodevelopmental delays, particularly in problem-solving ability, fine motor skills, and personal and social skills, were significantly higher in infants born to women with GDM than in those born to women without GDM (adjusted OR 1.24, 95% CI 1.12-1.36; adjusted OR 1.15, 95% CI 1.03-1.27; and adjusted OR 1.18, 95% CI 1.04-1.33). Furthermore, stratification showed no significant increase in the adjusted ORs (95% CIs) of girls. Conclusions Neurodevelopment was significantly delayed up to 4 years-of-age among boys born to women with GDM. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88792 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
