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Potential determinants of T helper 2 markers and their distribution in school-aged children

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Title: Potential determinants of T helper 2 markers and their distribution in school-aged children
Authors: Goudarzi, Houman Browse this author →KAKEN DB
Ikeda-Araki, Atsuko Browse this author →KAKEN DB
Bamai, Yu Ait Browse this author →KAKEN DB
Ito, Sachiko Browse this author
Inao, Tasuku Browse this author
Yokota, Isao Browse this author
Miyashita, Chihiro Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Keywords: Childhood allergies
Pre-and post-natal factors
Prospective birth cohort
School-age children
T helper 2 biomarkers
Issue Date: Jan-2023
Publisher: Japanese Society Allergology
Journal Title: Allergology international
Volume: 72
Issue: 1
Start Page: 100
End Page: 106
Publisher DOI: 10.1016/j.alit.2022.07.009
Abstract: Background: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 bio-markers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a pro-spective birth cohort.Methods: We examined the pre-and postnatal factors associated with Th2 biomarkers using multivar-iable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all exam-ined children and healthy participants without allergic diseases (n = 180).Results: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels.Conclusions: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are inde-pendent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.(c) 2022 Japanese Society of Allergology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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