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Star-Polymer-DNA Gels Showing Highly Predictable and Tunable Mechanical Responses

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/88857

Title: Star-Polymer-DNA Gels Showing Highly Predictable and Tunable Mechanical Responses
Authors: Ohira, Masashi Browse this author
Katashima, Takuya Browse this author
Naito, Mitsuru Browse this author
Aoki, Daisuke Browse this author
Yoshikawa, Yusuke Browse this author
Iwase, Hiroki Browse this author
Takata, Shin-Ichi Browse this author
Miyata, Kanjiro Browse this author
Chung, Ung-Il Browse this author
Sakai, Takamasa Browse this author
Shibayama, Mitsuhiro Browse this author
Li, Xiang Browse this author →KAKEN DB
Keywords: kinetics
self-assembly
stress relaxation
thermodynamics
viscoelasticity
Issue Date: 1-Apr-2022
Publisher: Wiley-Blackwell
Journal Title: Advanced Materials
Volume: 34
Issue: 13
Start Page: 2108818
Publisher DOI: 10.1002/adma.202108818
Abstract: Dynamically crosslinked gels are appealing materials for applications that require time-dependent mechanical responses. DNA duplexes are ideal crosslinkers for building such gels because of their excellent sequence addressability and flexible tunability in bond energy. However, the mechanical responses of most DNA gels are complicated and unpredictable. Here, a DNA gel with a highly homogeneous gel network and well predictable mechanical behaviors is demonstrated by using a pair of star-polymer-DNA precursors with presimulated DNA sequences showing the two-state transition. The melting curve analysis of the DNA gels reveals the good correspondence between the thermodynamic potentials of the DNA crosslinkers and the presimulated values by DNA calculators. Stress-relaxation tests and dissociation kinetics measurements show that the macroscopic relaxation time of the DNA gels is approximately equal to the lifetime of the DNA crosslinkers over 4 orders of magnitude from 0.1-2000 s. Furthermore, a series of durability tests find the DNA gels are hysteresis-less and self-healable after the applications of repeated temperature and mechanical stimuli. These results demonstrate the great potential of star-polymer-DNA precursors for building gels with predictable and tunable viscoelastic properties, suitable for applications such as stress-response extracellular matrices, injectable solids, and soft robotics.
Rights: This is the peer reviewed version of the following article: Ohira, M., Katashima, T., Naito, M., Aoki, D., Yoshikawa, Y., Iwase, H., Takata, S.-i., Miyata, K., Chung, U.-i., Sakai, T., Shibayama, M., Li, X., Star-Polymer–DNA Gels Showing Highly Predictable and Tunable Mechanical Responses. Adv. Mater. 2022, 34, 2108818, which has been published in final form at https://doi.org/10.1002/adma.202108818. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Type: article (author version)
URI: http://hdl.handle.net/2115/88857
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Xiang Li

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