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Prediction and Implications of Edoxaban-Associated Bleeding in Patients after Critical Illness

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Title: Prediction and Implications of Edoxaban-Associated Bleeding in Patients after Critical Illness
Authors: Mikami, Ryusei Browse this author
Hayakawa, Mineji Browse this author →KAKEN DB
Imai, Shungo Browse this author
Maekawa, Kunihiko Browse this author
Yamazaki, Kojiro Browse this author
Sugawara, Mitsuru Browse this author
Takekuma, Yoh Browse this author →KAKEN DB
Keywords: critical illness
bleeding score
Issue Date: Feb-2023
Publisher: MDPI
Journal Title: Journal of clinical medicine
Volume: 12
Issue: 3
Start Page: 860
Publisher DOI: 10.3390/jcm12030860
Abstract: In this retrospective study, we aimed to identify the risk factors for bleeding in patients after critical illness during edoxaban treatment. Data from patients who received edoxaban after critical illness at the Emergency Department at a tertiary care hospital were obtained from the hospital medical records. Multivariate analysis revealed the risk factors for edoxaban-associated bleeding. Additionally, we developed an edoxaban-associated bleeding score (EAB score) based on these results. The derived EAB score was compared with the HAS-BLED score using receiver operating characteristic (ROC) curve analysis. Bleeding was observed in 42 of 114 patients (36.8%). We identified the following bleeding predictors (odds ratios, 95% confidence interval, score points) using multivariate analysis: concomitant use of antiplatelet agents (6.759, 2.047-22.32, 2 points), concomitant use of P-glycoprotein inhibitors (3.825, 1.484-9.856, 1 point), prothrombin time (PT)% following edoxaban administration of <75% and >= 60% (2.507, 0.788-7.970, 1 point), and PT% following edoxaban administration of <60% (11.23, 3.560-35.42, 3 points). The ROC curve analysis revealed an area under the curve of 0.826 for the EAB score and 0.625 for the HAS-BLED score. Under appropriate edoxaban dosing regimens in patients after critical illness, a combination of antiplatelet agents, P-gp inhibitors, and a low PT% following edoxaban administration were identified as strong risk factors for bleeding.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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