HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments

Files in This Item:

The file(s) associated with this item can be obtained from the following URL:

Title: Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments
Authors: Endo, Tsutomu Browse this author →KAKEN DB
Takahata, Masahiko Browse this author
Fujita, Ryo Browse this author
Koike, Yoshinao Browse this author
Suzuki, Ryota Browse this author
Hasegawa, Yuichi Browse this author
Murakami, Toshifumi Browse this author
Ishii, Misaki Browse this author
Yamada, Katsuhisa Browse this author
Sudo, Hideki Browse this author →KAKEN DB
Iwasaki, Norimasa Browse this author →KAKEN DB
Issue Date: 30-Dec-2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Issue: 1
Start Page: 22617
Publisher DOI: 10.1038/s41598-022-27136-4
Abstract: Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals receiving health screening tests, including computed tomography. Subjects were grouped according to the presence or location of OPLL/OLF: controls (no OPLL/OLF, n=230), OLF (n=167), cervical OPLL (n=28), and thoracic OPLL (n=33). They were also grouped according to the presence of dyslipidemia (DL[+], n=215; DL[-], n=243). The proportion of dyslipidemia in the OLF and OPLL groups was 1.6-2.2 times higher than that in the control group. The proportion of OLF and OPLL in the DL(+) group was significantly higher than that in the DL(-) group (OLF, 43% vs. 29%; cervical OPLL, 14.4% vs. 3.2%; thoracic OPLL, 11.1% vs. 3.7%). Multivariate logistic regression analysis showed an association between all ossification types and dyslipidemia. This study demonstrated an association of dyslipidemia with OPLL/OLF; further investigation on the causal relationship between dyslipidemia and ectopic spinal ligament ossification is warranted to develop a therapeutic intervention for OPLL/OLF.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University