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Hokkaido University Collection of Scholarly and Academic Papers >
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Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments
| Title: | Strong relationship between dyslipidemia and the ectopic ossification of the spinal ligaments |
| Authors: | Endo, Tsutomu Browse this author →KAKEN DB | | Takahata, Masahiko Browse this author | | Fujita, Ryo Browse this author | | Koike, Yoshinao Browse this author | | Suzuki, Ryota Browse this author | | Hasegawa, Yuichi Browse this author | | Murakami, Toshifumi Browse this author | | Ishii, Misaki Browse this author | | Yamada, Katsuhisa Browse this author | | Sudo, Hideki Browse this author →KAKEN DB | | Iwasaki, Norimasa Browse this author →KAKEN DB |
| Issue Date: | 30-Dec-2022 |
| Publisher: | Nature Portfolio |
| Journal Title: | Scientific reports |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 22617 |
| Publisher DOI: | 10.1038/s41598-022-27136-4 |
| Abstract: | Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals receiving health screening tests, including computed tomography. Subjects were grouped according to the presence or location of OPLL/OLF: controls (no OPLL/OLF, n=230), OLF (n=167), cervical OPLL (n=28), and thoracic OPLL (n=33). They were also grouped according to the presence of dyslipidemia (DL[+], n=215; DL[-], n=243). The proportion of dyslipidemia in the OLF and OPLL groups was 1.6-2.2 times higher than that in the control group. The proportion of OLF and OPLL in the DL(+) group was significantly higher than that in the DL(-) group (OLF, 43% vs. 29%; cervical OPLL, 14.4% vs. 3.2%; thoracic OPLL, 11.1% vs. 3.7%). Multivariate logistic regression analysis showed an association between all ossification types and dyslipidemia. This study demonstrated an association of dyslipidemia with OPLL/OLF; further investigation on the causal relationship between dyslipidemia and ectopic spinal ligament ossification is warranted to develop a therapeutic intervention for OPLL/OLF. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88917 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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