| Title: | Efficacy of Quantitative Susceptibility Mapping with Brain Surface Correction and Vein Removal for Detecting Increase Magnetic Susceptibility in Patients with Alzheimer's Disease |
| Authors: | Yamaguchi, Akinori Browse this author |
| Kudo, Kohsuke Browse this author →KAKEN DB |
| Sato, Ryota Browse this author |
| Kawata, Yasuo Browse this author |
| Udo, Niki Browse this author |
| Matsushima, Masaaki Browse this author |
| Yabe, Ichiro Browse this author |
| Sasaki, Makoto Browse this author |
| Harada, Masafumi Browse this author |
| Matsukawa, Noriyuki Browse this author |
| Shirai, Toru Browse this author |
| Ochi, Hisaaki Browse this author |
| Bito, Yoshitaka Browse this author |
| Keywords: | Alzheimer?s disease |
| brain surface correction |
| cerebral cortex |
| quantitative susceptibility mapping |
| vein removal |
| Issue Date: | 2023 |
| Publisher: | Japanese Society for Magnetic Resonance in Medicine |
| Journal Title: | Magnetic resonance in medical sciences |
| Volume: | 22 |
| Issue: | 1 |
| Start Page: | 87 |
| End Page: | 94 |
| Publisher DOI: | 10.2463/mrms.mp.2021-0015 |
| Abstract: | Purpose: Studies on quantitative susceptibility mapping (QSM) have reported an increase in magnetic susceptibilities in patients with Alzheimer's disease (AD). Despite the pathological importance of the brain surface areas, they are sometimes excluded in QSM analysis. This study aimed to reveal the efficacy of QSMMethods: Thirty-seven AD patients and 37 age- and sex-matched, cognitively normal (CN) subjects were included. A 3D-gradient echo sequence at 3T MRI was used to obtain QSM. QSM images were created with regularization enabled sophisticated harmonic artifact reduction for phase data (RESHARP) and constrained RESHARP with BSC and/or VR. We conducted ROI analysis between AD patients and CN subjects who did or did not undergo BSC and/or VR using a t-test, to compare the susceptibility values after gray matter weighting. Results: The susceptibility values in RESHARP without BSC were significantly larger in AD patients than in CN subjects in one region (precentral gyrus, 8.1 +/- 2.9 vs. 6.5 +/- 2.1 ppb) without VR and one region with VR (precentral gyrus, 7.5 +/- 2.8 vs. 5.9 +/- 2.0 ppb). Three regions in RESHARP with BSC had significantly larger susceptibilities without VR (precentral gyrus, 7.1 +/- 2.0 vs. 5.9 +/- 2.0 ppb; superior medial frontal gyrus, 5.7 +/- 2.6 vs. 4.2 +/- 3.1 ppb; putamen, 47,8 +/- 16.5 vs. 40.0 +/- 15.9 ppb). In contrast, six regions showed significantly larger susceptibilities with VR in AD patients than in CN subjects (precentral gyrus, 6.4 +/- 1.9 vs. 4.9 +/- 2.7 ppb; superior medial frontal gyrus, 5.3 +/- 2.7 vs. 3.7 +/- 3.3 ppb; orbitofrontal cortex, -2.1 +/- 2.7 vs. -3.6 +/- 3.2 ppb; parahippocampal gyrus, 0.1 +/- 3.6 vs. -1.7 +/- 3.7 ppb; putamen, 45.0 +/- 14.9 vs. 37.6 +/- 14.6 ppb; inferior temporal gyrus, -3.4 +/- 1.5 vs. -4.4 +/- 1.5 ppb).Conclusion: RESHARP with BSC and VR showed more regions of increased susceptibility in AD patients than in CN subjects. This study highlights the efficacy of this method in facilitating the diagnosis of AD. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88924 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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