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Budget impact analysis of next-generation sequencing versus sequential single-gene testing in Japanese patients with advanced non-small-cell lung cancer
| Title: | Budget impact analysis of next-generation sequencing versus sequential single-gene testing in Japanese patients with advanced non-small-cell lung cancer |
| Authors: | Matsuda, Hiroyuki Browse this author | | Ogawa, Toru Browse this author | | Sadatsuki, Yasunari Browse this author | | Tsujino, Toshiaki Browse this author | | Wada, Shingo Browse this author | | Kim, Seok-Won Browse this author | | Hatanaka, Yutaka Browse this author →KAKEN DB |
| Keywords: | Non-small-cell lung cancer | | Sequential single-gene test | | Next generation sequencing | | Budget impact | | Turnaround times |
| Issue Date: | Jan-2023 |
| Publisher: | Elsevier |
| Journal Title: | Respiratory Investigation |
| Volume: | 61 |
| Issue: | 1 |
| Start Page: | 61 |
| End Page: | 73 |
| Publisher DOI: | 10.1016/j.resinv.2022.10.002 |
| Abstract: | Background: Identification of genomic alterations (e.g., EGFR, ALK, ROS1, BRAF, NTRK, and MET) is essential for initiating targeted therapy in patients with advanced non-small-cell lung cancer (aNSCLC). This study estimated the budget impact of using the sequential single-gene (SSG) test, which tests for each mutation one at a time, versus next-generation sequencing (NGS), which tests for all mutations at the same time, among newly diagnosed patients with aNSCLC from a Japanese healthcare payer's perspective. Methods: A budget impact model (BIM) was used to determine the expected budget impact associated with NGS for newly diagnosed aNSCLC in Japan over a 3-year period. The BIM compared the total costs (biopsy, testing, and treatment) and average turnaround time of future NGS and current NGS versus SSG testing. Results: The adoption of current NGS over SSG testing had a budget impact of-0.24%, but adoption of future NGS over SSG testing had a budget impact of thorn 4.33% across a 3-year time horizon on the Japanese budget for aNSCLC treatment. The adoption of current or future NGS over SSG testing would shorten the average turnaround time for testing. Conclusions: The adoption of current NGS over SSG testing would slightly decrease the yearly costs. However, the adoption of future or current NGS over SSG testing would shorten the average turnaround time, enabling faster identification of genomic alterations and earlier initiation of treatment for aNSCLC patients in Japan. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of The Japanese Respiratory So-ciety. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88929 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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