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CD44 as a pathological marker for the early detection of calcineurin inhibitor-induced nephrotoxicity post kidney transplantation
| Title: | CD44 as a pathological marker for the early detection of calcineurin inhibitor-induced nephrotoxicity post kidney transplantation |
| Authors: | Hayashi, Asako Browse this author | | Okamoto, Takayuki Browse this author →KAKEN DB | | Nio-Kobayashi, Junko Browse this author | | Iwahara, Naoya Browse this author | | Suzuki, Ryota Browse this author | | Ueda, Yasuhiro Browse this author | | Takahashi, Toshiyuki Browse this author | | Sato, Yasuyuki Browse this author | | Iwanaga, Toshihiko Browse this author | | Hotta, Kiyohiko Browse this author |
| Issue Date: | 14-Oct-2022 |
| Publisher: | Biomedical Research Press |
| Journal Title: | Biomedical Research (Tokyo) |
| Volume: | 43 |
| Issue: | 5 |
| Start Page: | 181 |
| End Page: | 186 |
| Publisher DOI: | 10.2220/biomedres.43.181 |
| Abstract: | Long-term calcineurin inhibitor (CNI) administration causes irreversible nephrotoxicity. Therefore, early CNI-induced nephrotoxicity detection is necessary for patients who will need long-term CNI administration. There is no pathological indicator for early CNI-induced nephrotoxicity. Here, serial protocol kidney biopsy specimens from five kidney-transplant patients with severe CNI-induced nephrotoxicity were examined. We observed that the increase in CD44 expression in glomerular parietal epithelial cells (PECs) preceded the chronic pathological changes of CNI-induced nephrotoxicity such as tubular atrophy/interstitial fibrosis, arterial hyaline thickening, and focal segmental glomerulosclerosis (FSGS). This result suggests that CD44-positive PECs have pivotal roles in FSGS development in human CNI-induced nephrotoxicity as well as rodent models. CD44 could be useful as a pathological marker for early CNI-induced nephrotoxicity detection post kidney transplantation. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88930 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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