| Title: | Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand : a randomized controlled trial |
| Authors: | Watanabe, Akihiro Browse this author |
| Sawamura, Daisuke Browse this author →KAKEN DB |
| Nakazono, Hisato Browse this author |
| Tokikuni, Yukina Browse this author |
| Miura, Hiroshi Browse this author |
| Sugawara, Kazuhiro Browse this author |
| Fuyama, Kanako Browse this author |
| Tohyama, Harukazu Browse this author →KAKEN DB |
| Yoshida, Susumu Browse this author |
| Sakai, Shinya Browse this author →KAKEN DB |
| Keywords: | Transcranial direct current stimulation |
| Motor learning |
| Dorsolateral prefrontal cortex |
| Non-dominant hand |
| Fine motor |
| Cognitive aspects |
| Issue Date: | 24-Feb-2023 |
| Publisher: | BioMed Central |
| Journal Title: | Journal of Translational Medicine |
| Volume: | 21 |
| Issue: | 1 |
| Start Page: | 143 |
| Publisher DOI: | 10.1186/s12967-023-03989-9 |
| PMID: | 36823635 |
| Abstract: | Background The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However, the effectiveness of left DLPFC transcranial direct current stimulation (tDCS) on early-phase motor learning and whether its effectiveness depends on the cognitive demand of the target task are unclear. This study aimed to investigate whether tDCS over the left DLPFC improves non-dominant hand dexterity performance and determine if its efficacy depends on the cognitive demand of the target task.Methods In this randomized, double-blind, sham-controlled trial, 70 healthy, right-handed, young adult participants were recruited. They were randomly allocated to the active tDCS (2 mA for 20 min) or sham groups and repeatedly performed the Purdue Pegboard Test (PPT) left-handed peg task and left-handed assembly task three times: pre-tDCS, during tDCS, and post tDCS.Results The final sample comprised 66 healthy young adults (mean age, 22.73 +/- 1.57 years). There were significant interactions between group and time in both PPT tasks, indicating significantly higher performance of those in the active tDCS group than those in the sham group post tDCS (p < 0.001). Moreover, a greater benefit was observed in the left-handed assembly task performance than in the peg task performance (p < 0.001). No significant correlation between baseline performance and benefits from tDCS was observed in either task.Conclusions These results demonstrated that prefrontal tDCS significantly improved early-phase manual dexterity skill acquisition, and its benefits were greater for the task with high cognitive demands. These findings contribute to a deeper understanding of the underlying neurophysiological mechanisms of the left DLPFC in the modulation of early-phase dexterity skill acquisition. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88946 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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