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Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation
| Title: | Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation |
| Authors: | Tsuji-Tamura, Kiyomi Browse this author →KAKEN DB | | Tamura, Masato Browse this author →KAKEN DB |
| Keywords: | bFGF | | cell quiescence | | TGF beta 1 | | TAGLN | | vascular endothelial cells | | vascular smooth muscle cells |
| Issue Date: | 1-Apr-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | FEBS Letters |
| Volume: | 596 |
| Issue: | 13 |
| Start Page: | 1686 |
| End Page: | 1699 |
| Publisher DOI: | 10.1002/1873-3468.14345 |
| PMID: | 35363891 |
| Abstract: | Blood vessels normally remain stable over the long term. However, in atherosclerosis, vascular cells leave the quiescent state and enter an activated state. Here, we investigated the factors that trigger the breakage of the quiescent state by screening growth factors and cytokines using a vascular smooth muscle cell (SMC) line and an endothelial cell (EC) line. Despite known functions of the tested factors, only basic fibroblast growth factor (bFGF) was identified as a potent trigger of quiescence breakage in SMCs, but not ECs. bFGF disrupted fight SMC-monolayers and caused morphological changes, proliferation, and dedifferentiation. Human primary SMCs, but not ECs, also showed similar results. Aberrant SMC proliferation is a critical histological event in atherosclerosis. We, thus, provide further insights into the role of bFGF in vascular pathobiology. |
| Rights: | This is the peer reviewed version of the following article: Tsuji-Tamura K, Tamura M. Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation. FEBS Lett. 2022 Jul;596(13):1686-1699. , which has been published in final form at https://doi.org/10.1002/1873-3468.14345. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88997 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 田村（辻） 潔美
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