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Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent

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Title: Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent
Authors: Jin, Zhiping Browse this author
Fan, Hailong Browse this author →KAKEN DB
Osanai, Toshiya Browse this author →KAKEN DB
Nonoyama, Takayuki Browse this author →KAKEN DB
Kurokawa, Takayuki Browse this author →KAKEN DB
Hyodoh, Hideki Browse this author →KAKEN DB
Matoba, Kotaro Browse this author →KAKEN DB
Takeuchi, Akiko Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Fujimura, Miki Browse this author →KAKEN DB
Keywords: liquid embolic agent
electrostatic interaction
adjacent sequence
Issue Date: 10-Oct-2022
Publisher: National Academy of Sciences.
Journal Title: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Volume: 119
Issue: 42
Start Page: e2206685119
Publisher DOI: 10.1073/pnas.2206685119
Abstract: Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents.
Type: article
URI: http://hdl.handle.net/2115/89037
Appears in Collections:化学反応創成研究拠点:ICReDD (Institute for Chemical Reaction Design and Discovery : ICReDD) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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