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Genetic, Antigenic, and Pathobiological Characterization of H9 and H6 Low Pathogenicity Avian Influenza Viruses Isolated in Vietnam from 2014 to 2018

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Title: Genetic, Antigenic, and Pathobiological Characterization of H9 and H6 Low Pathogenicity Avian Influenza Viruses Isolated in Vietnam from 2014 to 2018
Authors: Le, Kien Trung Browse this author
Nguyen, Lam Thanh Browse this author
Huynh, Loc Tan Browse this author
Chu, Duc-Huy Browse this author
Nguyen, Long Van Browse this author
Nguyen, Tien Ngoc Browse this author
Tien, Tien Ngoc Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Okamatsu, Masatoshi Browse this author
Hiono, Takahiro Browse this author →KAKEN DB
Isoda, Norikazu Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: coinfection
Escherichia coli O2
low pathogenicity avian influenza
pathogenicity assessment
surveillance
Vietnam
Issue Date: 18-Jan-2023
Publisher: MDPI
Journal Title: Microorganisms
Volume: 11
Issue: 2
Start Page: 244
Publisher DOI: 10.3390/microorganisms11020244
Abstract: The H9 and H6 subtypes of low pathogenicity avian influenza viruses (LPAIVs) cause substantial economic losses in poultry worldwide, including Vietnam. Herein, we characterized Vietnamese H9 and H6 LPAIVs to facilitate the control of avian influenza. The space-time representative viruses of each subtype were selected based on active surveillance from 2014 to 2018 in Vietnam. Phylogenetic analysis using hemagglutinin genes revealed that 54 H9 and 48 H6 Vietnamese LPAIVs were classified into the sublineages Y280/BJ94 and Group II, respectively. Gene constellation analysis indicated that 6 and 19 genotypes of the H9 and H6 subtypes, respectively, belonged to the representative viruses. The Vietnamese viruses are genetically related to the previous isolates and those in neighboring countries, indicating their circulation in poultry after being introduced into Vietnam. The antigenicity of these subtypes was different from that of viruses isolated from wild birds. Antigenicity was more conserved in the H9 viruses than in the H6 viruses. Furthermore, a representative H9 LPAIV exhibited systemic replication in chickens, which was enhanced by coinfection with avian pathogenic Escherichia coli O2. Although H9 and H6 were classified as LPAIVs, their characterization indicated that their silent spread might significantly affect the poultry industry.
Type: article
URI: http://hdl.handle.net/2115/89156
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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