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Prognostic factors in patients in the terminal phase of haematological malignancies who are receiving home medical care
| Title: | Prognostic factors in patients in the terminal phase of haematological malignancies who are receiving home medical care |
| Authors: | Miyashita, Naohiro Browse this author | | Ohashi, Kota Browse this author | | Fujita, Mariko Browse this author | | Hosoda, Toru Browse this author | | Kawasaki, Yasufumi Browse this author | | Takimoto, Madoka Browse this author | | Onozawa, Masahiro Browse this author →KAKEN DB |
| Keywords: | haematological malignancies | | home medical care | | Japan palliative haematological oncology prognostic estimates | | JPHOPE | | prognostic factors | | quality of life |
| Issue Date: | Apr-2023 |
| Publisher: | John Wiley & Sons |
| Journal Title: | British journal of haematology |
| Volume: | 201 |
| Issue: | 2 |
| Start Page: | 290 |
| End Page: | 301 |
| Publisher DOI: | 10.1111/bjh.18623 |
| Abstract: | Although there are many prognostic models for patients in the terminal phase of solid tumours, a reliable prognostic scoring system in patients in the terminal phase of haematological malignancies (HM) has not been established. We retrospectively evaluated 180 patients in the terminal phase of HM who were receiving home medical care (HMC). Multivariate analyses revealed that clinician's estimate, consciousness, loss of appetite, dyspnoea, neutrophil count, lymphocyte count, and lactate dehydrogenase were associated with overall survival (OS). Based on this result, we developed a novel prognostic scoring system, the Japan palliative haematological oncology prognostic estimates, in which four risk groups were shown to clearly differ in survival (p < 0.001): a low-risk group (n = 41, median OS of 434 days), an intermediate-low-risk group (n = 80, median OS of 112 days), an intermediate-high-risk group (n = 38, median OS of 31.5 days), and a high-risk group (n = 21, median OS of 10 days). This is the first investigation of prognostic factors that influence the OS of patients in the terminal phase of HM who are receiving HMC. Providing patients with reliable information about their prognosis is important for them to consider how to spend their remaining life. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89177 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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