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Hokkaido University Collection of Scholarly and Academic Papers >
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Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking : report of a case
| Title: | Dedifferentiated liposarcoma primary to the chest wall with spontaneous shrinking : report of a case |
| Authors: | Itagaki, Yuki Browse this author | | Fukunaga, Akira Browse this author | | Takano, Hironobu Browse this author | | Yamamoto, Kazuyuki Browse this author | | Nishigami, Kohei Browse this author | | Ichimura, Tatsunosuke Browse this author | | Manase, Hiroto Browse this author | | Obata, Masahiko Browse this author | | Kato, Tatsuya Browse this author | | Hirano, Satoshi Browse this author →KAKEN DB |
| Issue Date: | 15-Feb-2023 |
| Publisher: | Springer |
| Journal Title: | Surgical case reports |
| Volume: | 9 |
| Issue: | 1 |
| Start Page: | 26 |
| Publisher DOI: | 10.1186/s40792-023-01606-x |
| Abstract: | An 80-year-old man presented to our emergency department complaining of a mass on the right side of his chest and pain in the right flank of his back. A chest computed tomography (CT) scan showed a relatively heterogenous oval-shaped tumor measuring 7.5 x 6.0 cm eroded to the 8th rib, with slightly dense fluid accumulation inside and calcification of the tumor wall. A 1-month follow-up CT scan showed spontaneous shrinkage of the tumor. The tumor was completely excised from the thoracic wall and the wall was reconstructed with a polytetrafluoroethylene mesh. Pathological examination showed coagulation necrosis in the chest wall tumor, but immunohistochemical staining revealed murine double minute 2- and Cyclin-dependent kinase 4-positive cells with irregular nuclear size and bizarre morphology. Therefore, dedifferentiated liposarcoma (DDLPS) was the final pathological diagnosis. Remarkable infiltration of CD8+ lymphocytes into the tumor was observed, along with a 90% positive ratio for programmed cell death-ligand 1. The patient has been followed-up for 1 year without any recurrence, despite not receiving any additional treatment. Liposarcoma is one of the most common types of soft tissue sarcomas; however, spontaneous regression of primary DDLPS arising from the chest wall is extremely rare. Herein, we report a case of DDLPS primary to the chest wall with spontaneous regression, probably due to a spontaneously induced T cell response. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89270 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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