| Title: | Relationships of computed tomography-based small vessel indices of the lungs with ventilation heterogeneity and high transfer coefficients in non-smokers with asthma |
| Authors: | Shimizu, Kaoruko Browse this author →KAKEN DB |
| Kimura, Hirokazu Browse this author |
| Tanabe, Naoya Browse this author |
| Chubachi, Shotaro Browse this author |
| Sato, Susumu Browse this author |
| Suzuki, Masaru Browse this author |
| Tanimura, Kazuya Browse this author |
| Iijima, Hiroaki Browse this author |
| Oguma, Akira M. Browse this author |
| Ito, Yoichi Browse this author |
| Wakazono, Nobuyasu Browse this author |
| Takimoto-Sato, Michiko Browse this author |
| Matsumoto-Sasaki, Machiko Browse this author |
| Abe, Yuki Browse this author |
| Takei, Nozomu Browse this author |
| Makita, Hironi Browse this author |
| Nishimura, Masaharu Browse this author |
| Konno, Satoshi Browse this author →KAKEN DB |
| Hi CARAT Investigators Browse this author |
| Keywords: | asthma |
| computed tomography |
| pulmonary small vessels |
| ventilation heterogeneity |
| Kco |
| Issue Date: | 1-Mar-2023 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in physiology |
| Volume: | 14 |
| Start Page: | 1137603 |
| Publisher DOI: | 10.3389/fphys.2023.1137603 |
| Abstract: | Background: The mechanism of high transfer coefficients of the lungs for carbon monoxide (Kco) in non-smokers with asthma is explained by the redistribution of blood flow to the area with preserved ventilation, to match the ventilation perfusion.Objectives: To examine whether ventilation heterogeneity, assessed by pulmonary function tests, is associated with computed tomography (CT)-based vascular indices and Kco in patients with asthma.Methods: Participants were enrolled from the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) study that included a prospective asthmatic cohort. Pulmonary function tests including Kco, using single breath methods; total lung capacity (TLC), using multiple breath methods; and CT, were performed on the same day. The ratio of the lung volume assessed using single breath methods (alveolar volume; V-A) to that using multiple breath methods (TLC) was calculated as an index of ventilation heterogeneity. The volume of the pulmonary small vessels < 5 mm(2) in the whole lung (BV5 volume), and number of BV5 at a theoretical surface area of the lungs from the plural surface (BV5 number) were evaluated using chest CT images.Results: The low V-A/TLC group (the lowest quartile) had significantly lower BV5 number, BV5 volume, higher BV5 volume/BV5 number, and higher Kco compared to the high V-A/TLC group (the highest quartile) in 117 non-smokers, but not in 67 smokers. Multivariable analysis showed that low V-A/TLC was associated with low BV5 number, after adjusting for age, sex, weight, lung volume on CT, and CT emphysema index in non-smokers (not in smokers).Conclusion: Ventilation heterogeneity may be associated with low BV5 number and high Kco in non-smokers (not in smokers). Future studies need to determine the dynamic regional system in ventilation, perfusion, and diffusion in asthma. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89273 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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