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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk
| Title: | Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk |
| Authors: | Teramoto, Masayuki Browse this author | | Iso, Hiroyasu Browse this author | | Wakai, Kenji Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB |
| Keywords: | cancer mortality | | parental smoking | | passive smoking | | secondhand smoke |
| Issue Date: | 1-May-2022 |
| Publisher: | Oxford University Press |
| Journal Title: | American Journal of Epidemiology |
| Volume: | 191 |
| Issue: | 5 |
| Start Page: | 834 |
| End Page: | 842 |
| Publisher DOI: | 10.1093/aje/kwab284 |
| Abstract: | We examined whether secondhand smoke exposure during childhood was associated with cancer mortality in adulthood among never smokers. In the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, we analyzed data from 45,722 Japanese lifetime nonsmokers aged 40-79 years with no history of cancer at baseline (1988-1990) who had completed a lifestyle questionnaire, including information on the number of family members who had smoked at home during their childhood (0, 1, 2, or >= 3 family members). A Cox proportional hazards model and competing-risks regression were used to calculate multivariable hazard ratios and subdistribution hazard ratios with 95% confidence intervals for overall and site-specific cancer mortality according to the number of family members who smoked during the participant's childhood, after adjusting for potentially confounding factors. During a median follow-up period of 19.2 years, a total of 2,356 cancer deaths were documented. Secondhand smoke exposure was positively associated with the risk of mortality from pancreatic cancer in adulthood; the multivariable hazard ratio for having 3 or more family members who smoked (as compared with none) was 2.32 (95% confidence interval: 1.14, 4.72). Associations were not evident for total cancer risk or risk of other types of smoking-related cancer. In this study, secondhand smoke exposure during childhood was associated with an increased risk of pancreatic cancer mortality in adulthood. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record Masayuki Teramoto, Hiroyasu Iso, Kenji Wakai, Akiko Tamakoshi, Secondhand Smoke Exposure During Childhood and Cancer Mortality in Adulthood Among Never Smokers: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk, American Journal of Epidemiology, Volume 191, Issue 5, May 2022, Pages 834–842 is available online at: https://doi.org/10.1093/aje/kwab284 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/89280 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉腰 暁子
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